ID A0A7N5K6J0_AILME Unreviewed; 851 AA.
AC A0A7N5K6J0;
DT 02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE SubName: Full=Zinc finger protein 598, E3 ubiquitin ligase {ECO:0000313|Ensembl:ENSAMEP00000035818.1};
GN Name=ZNF598 {ECO:0000313|Ensembl:ENSAMEP00000035818.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000035818.1, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000035818.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000035818.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSAMEP00000035818.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
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DR RefSeq; XP_034526504.1; XM_034670613.1.
DR AlphaFoldDB; A0A7N5K6J0; -.
DR Ensembl; ENSAMET00000048907.1; ENSAMEP00000035818.1; ENSAMEG00000017681.2.
DR GeneID; 117804196; -.
DR KEGG; aml:117804196; -.
DR CTD; 90850; -.
DR GeneTree; ENSGT00390000014178; -.
DR InParanoid; A0A7N5K6J0; -.
DR OrthoDB; 3838338at2759; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0043022; F:ribosome binding; IEA:TreeGrafter.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:TreeGrafter.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:InterPro.
DR InterPro; IPR057634; PAH_ZNF598/HEL2.
DR InterPro; IPR056437; Znf-C2H2_ZNF598/HEL2.
DR InterPro; IPR044288; ZNF598/HEL2.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR059042; Znf_C2H2_ZNF598.
DR PANTHER; PTHR22938:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZNF598; 1.
DR PANTHER; PTHR22938; ZINC FINGER PROTEIN 598; 1.
DR Pfam; PF23202; PAH_ZNF598; 1.
DR Pfam; PF25447; RING_ZNF598; 1.
DR Pfam; PF23230; zf-C2H2_13; 1.
DR Pfam; PF23208; zf_C2H2_ZNF598; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 127..148
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS00028"
FT REGION 218..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..301
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..402
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..487
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..613
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 93016 MW; 986B3F73BBD0B52A CRC64;
MVLLTSPLTW FQVVFGKKLP AFATIPLQQL QYEKKYDIYF ADGKVFALYR QLLQHECPQC
PELPPFGLFG DLEQHMRKQH ELFCCKLCLK HLKIFTYERK WYSRKDLARH RMQGDPDDTS
HRGHPLCKFC DERYLDNDEL LKHLRRDHYF CHFCDSDGAQ DYYSDYAYLR EHFREKHFLC
EEGRCSTEQF THAFRTEIDL KAHRTACHSR SRAEARQNRQ IDLQFSYAPR HSRRNEGVVG
GEDYEEVDRY NRQGRTGRAS GRGAQQSRRG SWRYKREEED REVAAAIRAS VAAQQQQQQQ
QETRRSEDRE EGGRAKKEEA GLRGLEEPRG PRRPPRTQGE GAGLKEASPN GPVSQEGLPA
PGPATGTMLP STLPPPTSKL KDEDFPSLCA STSSSSSSSC SAATALGPVG LALAYPVPAR
GRSTFQEDDF PALVSSACKP STAPTSLISA WNSSSSKKVA HPSTGAQAAG GSSQPPRKAG
KGGKGSKKGG LPPSEEEEED GRAGLTAQEL RSVPTTVAVS SLLALASTQT VTKVGKKKKV
GSEKAGAASP PPLPPDKDGP PGAGQAPTTT AGRAEGPIAL IVNGHTEGPA PARSTPKEPP
GLPRPLGPLP CPTPQEDFPA LGVPCPPRMP PPPGFNAVVL LKGTPPPPPP GLVPPVSKPP
PGFSGLLPSP HPACVPSTAT TTKAPRLTPT PQAYLVPENF RERNLQLIQS IKDFLQSDEA
RFGKFKSHSG EFRQGVISAA QYYKSCRDLL GENFQKIFNE LLVLLPDTAK QQELLSAHTH
FRGRDRPPGT KAKKNKKSAW QASTRPAGLD CCVCPTCQQV LAHGDVSSHQ ALHAAQDNDF
PSLQAIARIL T
//
