ID A0A7N9AQ52_9TELE Unreviewed; 449 AA.
AC A0A7N9AQ52;
DT 02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 1.
DT 18-JUN-2025, entry version 20.
DE SubName: Full=Protein kinase C and casein kinase substrate in neurons 1 {ECO:0000313|Ensembl:ENSMAMP00000053838.1};
GN Name=PACSIN1 {ECO:0000313|Ensembl:ENSMAMP00000053838.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000053838.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000053838.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection,
CC ruffle membrane {ECO:0000256|ARBA:ARBA00004632}. Cytoplasmic vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004284}.
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DR AlphaFoldDB; A0A7N9AQ52; -.
DR FunCoup; A0A7N9AQ52; 783.
DR Ensembl; ENSMAMT00000043020.1; ENSMAMP00000053838.1; ENSMAMG00000024168.2.
DR GeneTree; ENSGT00950000182973; -.
DR InParanoid; A0A7N9AQ52; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005768; C:endosome; IEA:TreeGrafter.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005543; F:phospholipid binding; IEA:TreeGrafter.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:TreeGrafter.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:TreeGrafter.
DR GO; GO:0097320; P:plasma membrane tubulation; IEA:TreeGrafter.
DR GO; GO:1900006; P:positive regulation of dendrite development; IEA:TreeGrafter.
DR GO; GO:0030100; P:regulation of endocytosis; IEA:TreeGrafter.
DR CDD; cd11998; SH3_PACSIN1-2; 1.
DR FunFam; 2.30.30.40:FF:000014; Kinase C and casein kinase substrate in neurons protein; 1.
DR FunFam; 1.20.1270.60:FF:000205; Protein kinase C and casein kinase substrate in neurons protein 1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035743; PACSIN1/PACSIN2_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF23; PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS 1A; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 20..292
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 390..449
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 183..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 51282 MW; E556AABC9C0DE7CD CRC64;
MHVFKVSTHT QSLVSICISV STSSSIPCLP VGNYKRVVKR FDDGHRLCND LMSCLQERAK
IEKAYGDQLT VWSKRWRQLI EKGPQYGSVE RAWLAVMTEA EKVSELHQEV KNNLLNDDNE
KVKNWQKEAY HKQMIGGFKE AKEAEEGFKK AQKPWAKKLK EMETAKKSYH MACKEEKLAA
AREANGKTEA SVTPDQQKKL HEKVDKCKQD SQKAKEKYEK SLEELNKCTP GYMESMEQVF
DQCQQHEVKR LTFLKEALLD IKRHLNLTEN QSYATIYREL ERTILAANTQ EDLKWFSNNH
GPGMHMNWPA FEEYNPDQAT APPKKKKPDG APPTPSTDHV APPGDRSSVS SYDKNQAYST
EWSDDEQPAA YSGNENGGNG NSFEDDSSTG KEVRVRALYD YDGQEQDELS FKAGDELTKT
EDEDEQGWCR GRLDDGREGL YPANYVEPI
//
