ID A0A7R5L3V0_9PASS Unreviewed; 696 AA.
AC A0A7R5L3V0;
DT 02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE SubName: Full=Forkhead box protein P1 {ECO:0000313|RefSeq:XP_039244284.1};
GN Name=FOXP1 {ECO:0000313|RefSeq:XP_039244284.1};
OS Pipra filicauda (Wire-tailed manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Pipridae; Pipra.
OX NCBI_TaxID=649802 {ECO:0000313|Proteomes:UP000504627, ECO:0000313|RefSeq:XP_039244284.1};
RN [1] {ECO:0000313|RefSeq:XP_039244284.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_039244284.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_039244284.1; XM_039388350.1.
DR AlphaFoldDB; A0A7R5L3V0; -.
DR FunCoup; A0A7R5L3V0; 366.
DR GeneID; 113982256; -.
DR CTD; 27086; -.
DR InParanoid; A0A7R5L3V0; -.
DR Proteomes; UP000504627; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR CDD; cd20065; FH_FOXP2; 1.
DR FunFam; 1.20.5.340:FF:000005; Forkhead box P1, isoform CRA_f; 1.
DR FunFam; 1.10.10.10:FF:000010; Forkhead box P2 isoform B; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047412; FH_FOXP1_P2.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR050998; FOXP.
DR InterPro; IPR032354; FOXP-CC.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR PANTHER; PTHR45796:SF3; FORKHEAD BOX PROTEIN P1; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16159; FOXP-CC; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000504627};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 471..544
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 471..544
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..425
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..696
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 696 AA; 77783 MW; 09B820C6996BDEA3 CRC64;
MMQESGTETK SNGSAIQNGA SGGNHLLECS LREVRSNGET PSVEIGAADL AHLQQQQALQ
VARQLLLQQQ QQQQQQQQQQ QQVSGLKSPK RNDKQPALQV PVSVAMMTPQ VITPQQMQQI
LQQQVLTPQQ LQVLLQQQQA LMLQQQQLQE FYKKQQEQLQ LQLLQQQHAG KQPKEPQQQQ
VATQQLAFQQ QLLQMQQLQQ QHLLSLQRQG LLTIQPGQPT LPLQPLAQGM IPTELQQLWK
EVTSSHTAEE AASNNHSSLD LSTTCVSSSA PSKTSLIINP HASTNGQLSV HTPKRESLSH
EEHSHSHPLY GHGVCKWPGC EAVCEDFQSF LKHLNSEHAL DDRSTAQCRV QMQVVQQLEL
QLAKDKERLQ AMMTHLHVKS TEPKATPQPL NLVSSVTLSK TASEASPQSL PHTPTTPTAP
ITPVTQGPSV ITTTSMHNVG PIRRRYSDKY NVPISSDIAQ NQEFYKNAEV RPPFTYASLI
RQAILESPEK QLTLNEIYNW FTRMFAYFRR NAATWKNAVR HNLSLHKCFV RVENVKGAVW
TVDELEFQKR RPQKISGNPS LIKNIQTSHT YCTPLNAALQ GEEAALSPLC LWKASMAENS
IPLYTTASMG NPTLGNLASA MREELNGAME HTNSNGSDSS PGRSPMQAMH PVHVKEEPLD
PDENEGPLSL VTTANHSPDF DHDRDYEDEP VNEDIE
//
