ID A0A7R6T0C4_9BACT Unreviewed; 291 AA.
AC A0A7R6T0C4;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 18-JUN-2025, entry version 13.
DE RecName: Full=Heme exporter protein C {ECO:0000256|ARBA:ARBA00016463};
GN ORFNames=TTHT_2172 {ECO:0000313|EMBL:BBB33600.1};
OS Thermotomaculum hydrothermale.
OC Bacteria; Pseudomonadati; Acidobacteriota; Holophagae; Thermotomaculales;
OC Thermotomaculaceae; Thermotomaculum.
OX NCBI_TaxID=981385 {ECO:0000313|EMBL:BBB33600.1, ECO:0000313|Proteomes:UP000595564};
RN [1] {ECO:0000313|EMBL:BBB33600.1, ECO:0000313|Proteomes:UP000595564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AC55 {ECO:0000313|EMBL:BBB33600.1,
RC ECO:0000313|Proteomes:UP000595564};
RX PubMed=22212657; DOI=10.1007/s00792-011-0425-9;
RA Izumi H., Nunoura T., Miyazaki M., Mino S., Toki T., Takai K., Sako Y.,
RA Sawabe T., Nakagawa S.;
RT "Thermotomaculum hydrothermale gen. nov., sp. nov., a novel heterotrophic
RT thermophile within the phylum Acidobacteria from a deep-sea hydrothermal
RT vent chimney in the Southern Okinawa Trough.";
RL Extremophiles 16:245-253(2012).
CC -!- FUNCTION: Required for the export of heme to the periplasm for the
CC biogenesis of c-type cytochromes. {ECO:0000256|ARBA:ARBA00002442}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CcmC/CycZ/HelC family.
CC {ECO:0000256|ARBA:ARBA00005840}.
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DR EMBL; AP017470; BBB33600.1; -; Genomic_DNA.
DR RefSeq; WP_201327913.1; NZ_AP017470.1.
DR AlphaFoldDB; A0A7R6T0C4; -.
DR KEGG; thyd:TTHT_2172; -.
DR Proteomes; UP000595564; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0009579; C:thylakoid; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR003557; Cyt_c_biogenesis_CcmC.
DR InterPro; IPR017562; Cyt_c_biogenesis_CcsA.
DR InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR NCBIfam; TIGR03144; cytochr_II_ccsB; 1.
DR PANTHER; PTHR30071:SF1; CYTOCHROME B_B6 PROTEIN-RELATED; 1.
DR PANTHER; PTHR30071; HEME EXPORTER PROTEIN C; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR PRINTS; PR01386; CCMCBIOGNSIS.
PE 3: Inferred from homology;
KW Cytochrome c-type biogenesis {ECO:0000256|ARBA:ARBA00022748};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000595564};
KW Thylakoid {ECO:0000256|ARBA:ARBA00023078};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 74..278
FT /note="Cytochrome c assembly protein"
FT /evidence="ECO:0000259|Pfam:PF01578"
SQ SEQUENCE 291 AA; 33311 MW; 536F9C1EEF1E5638 CRC64;
MITLIENFSR INTFLFALIW VYFIAFIIYT VSLFSRSKGL YAFGRITLFI GFLINGYLII
QRWIQAGRPP FKTFYESLIF ASFCIILVYL VIELFRKVKI VGAASILMSL GCLLFAVVKV
DVEIINLPPA LQSGWFIPHV VIYFVGYGAL AVSFATGILY LFFPDKIELK GDTKWSNFLI
NALGGEVIDL EEFTHQLIIV GFTFLNLGLI TGSLWAKFAW GDYWFWDPKE NWSLITWLIY
ISYFHLRYVK GWRGRKAVIF AIIGFLAVVF TYLGMSVLPT ASMSEHVYTG S
//
