ID A0A7R7W4F9_ASPKA Unreviewed; 435 AA.
AC A0A7R7W4F9;
DT 02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 1.
DT 10-JUN-2026, entry version 20.
DE RecName: Full=Prephenate dehydrogenase [NADP(+)] {ECO:0000256|PIRNR:PIRNR036510};
DE Short=PRDH {ECO:0000256|PIRNR:PIRNR036510};
DE EC=1.3.1.13 {ECO:0000256|PIRNR:PIRNR036510};
GN Name=TYR1 {ECO:0000313|EMBL:BCR96179.1};
GN ORFNames=AKAW2_21119S {ECO:0000313|EMBL:BCR96179.1};
OS Aspergillus kawachii (White koji mold) (Aspergillus awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=1069201 {ECO:0000313|EMBL:BCR96179.1, ECO:0000313|Proteomes:UP000661280};
RN [1] {ECO:0000313|EMBL:BCR96179.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:BCR96179.1};
RG Aspergillus luchuensis mut. kawachii IFO 4304 genome sequencing consortium;
RA Kazuki M., Futagami T.;
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BCR96179.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:BCR96179.1};
RA Mori K., Kadooka C., Goto M., Futagami T.;
RT "Aspergillus luchuensis mut. kawachii IFO 4304 genome sequence.";
RL Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC NADPH; Xref=Rhea:RHEA:21640, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC ChEBI:CHEBI:36242, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.13;
CC Evidence={ECO:0000256|ARBA:ARBA00051295,
CC ECO:0000256|PIRNR:PIRNR036510};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00060605, ECO:0000256|PIRNR:PIRNR036510}.
CC -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007964, ECO:0000256|PIRNR:PIRNR036510}.
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DR EMBL; AP024426; BCR96179.1; -; Genomic_DNA.
DR RefSeq; XP_041539945.1; XM_041685908.1.
DR AlphaFoldDB; A0A7R7W4F9; -.
DR GeneID; 64957504; -.
DR KEGG; aluc:AKAW2_21119S; -.
DR OrthoDB; 5399569at2759; -.
DR UniPathway; UPA00122; UER00962.
DR Proteomes; UP000661280; Chromosome 2.
DR GO; GO:0070403; F:NAD+ binding; IEA:TreeGrafter.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006571; P:L-tyrosine biosynthetic process; IEA:UniProtKB-UniRule.
DR FunFam; 1.10.3660.10:FF:000002; Prephenate dehydrogenase [NADP(+)]; 1.
DR FunFam; 1.10.3660.10:FF:000004; Prephenate dehydrogenase [NADP(+)]; 1.
DR FunFam; 3.40.50.720:FF:000339; Prephenate dehydrogenase [NADP(+)]; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR050812; Preph/Arog_dehydrog.
DR InterPro; IPR003099; Prephen_DH.
DR InterPro; IPR012385; Prephenate_DH_fun.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF27505; 6PGD_Tyr1_C; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR Pfam; PF20463; PDH_C; 1.
DR PIRSF; PIRSF036510; PDH_fung; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605,
KW ECO:0000256|PIRNR:PIRNR036510};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141,
KW ECO:0000256|PIRNR:PIRNR036510};
KW NADP {ECO:0000256|ARBA:ARBA00022857, ECO:0000256|PIRNR:PIRNR036510};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036510};
KW Reference proteome {ECO:0000313|Proteomes:UP000661280};
KW Tyrosine biosynthesis {ECO:0000256|ARBA:ARBA00022498,
KW ECO:0000256|PIRNR:PIRNR036510}.
SQ SEQUENCE 435 AA; 48982 MW; 972B36D99115B0FA CRC64;
MGFTKESATI GIIGMGDMGK MYAQRLSAAG WRINACDKPD SYERLIKEFE STQNVTIFPN
GHLVSRISDY IIYSVEAGVI DKVVEMYGPS TKVGAIVGGQ TSCKAPELAA FDKHLPKDVE
IVSCHSLHGP QVNPKGQPLV LIQHRASDES LNFVKEVLSC FESKFVFLSG EMHDRITADT
QAVTHAAFLS MGTAWQANQQ FPWEINRWVG GIENVKINIT LRIYSNKWHV YAGLAILNPA
AKKQIRQYAE SVTDLYKLMI EGRRDELKRR VRAAGEAVFK AGTNGQDLLL KDEVLDRFSL
SNREREQAPP NSHLSLLAIV DCWSKLGIVP YDHMICSTPL FRLWLGVTEY LFRNPELLEA
ALDTAVDDKT FRSDDLEFTF AARAWSDCVS FGDFESYRDR FERIQQYFAP RFPEAVKLGN
EMMKTILEKT ATGQA
//
