ID A0A7R9LH76_9ACAR Unreviewed; 676 AA.
AC A0A7R9LH76;
DT 02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 1.
DT 18-JUN-2025, entry version 13.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189};
DE AltName: Full=Galactowaldenase {ECO:0000256|ARBA:ARBA00033067};
DE AltName: Full=UDP-galactose 4-epimerase {ECO:0000256|ARBA:ARBA00031367};
DE Flags: Fragment;
GN ORFNames=ONB1V03_LOCUS2502 {ECO:0000313|EMBL:CAD7640339.1};
OS Oppiella nova.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Oribatida; Brachypylina; Oppioidea; Oppiidae;
OC Oppiella.
OX NCBI_TaxID=334625 {ECO:0000313|EMBL:CAD7640339.1};
RN [1] {ECO:0000313|EMBL:CAD7640339.1}
RP NUCLEOTIDE SEQUENCE.
RA Tran Van P.;
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083};
CC -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC {ECO:0000256|ARBA:ARBA00007430}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; OC915415; CAD7640339.1; -; Genomic_DNA.
DR EMBL; CAJPVJ010000590; CAG2162915.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7R9LH76; -.
DR OrthoDB; 2735536at2759; -.
DR Proteomes; UP000728032; Unassembled WGS sequence.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:InterPro.
DR CDD; cd07007; cupin_CapF-like_C; 1.
DR CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR013692; CapD_C.
DR InterPro; IPR029303; CapF_C.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003869; Polysac_CapD-like.
DR InterPro; IPR051203; Polysaccharide_Synthase-Rel.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; NF047837; UDPAcbARedWbcJ; 1.
DR PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR PANTHER; PTHR43318:SF2; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE (INVERTING); 1.
DR Pfam; PF01370; Epimerase; 1.
DR Pfam; PF08485; Polysacc_syn_2C; 1.
DR Pfam; PF02719; Polysacc_synt_2; 1.
DR Pfam; PF14667; Polysacc_synt_C; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Lipopolysaccharide biosynthesis {ECO:0000256|ARBA:ARBA00022985};
KW Reference proteome {ECO:0000313|Proteomes:UP000728032}.
FT DOMAIN 1..271
FT /note="Polysaccharide biosynthesis protein CapD-like"
FT /evidence="ECO:0000259|Pfam:PF02719"
FT DOMAIN 274..308
FT /note="UDP-glucose 4-epimerase CapD C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08485"
FT DOMAIN 309..493
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT DOMAIN 561..670
FT /note="Capsular polysaccharide assembling protein CapF C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF14667"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAD7640339.1"
FT NON_TER 676
FT /evidence="ECO:0000313|EMBL:CAD7640339.1"
SQ SEQUENCE 676 AA; 76656 MW; 28953882A480BAF9 CRC64;
GTGSFGNAVL KRFLDSDFKE IRIFSRDEKK QDDMRKKYQS SKLKFYIGDV RDFNSVLNVT
RGVDYIFHAA ALKQVPSCEF YPLEAVKTNV LGTENLLEAA IQNKVSRVVC LSTDKAVYPI
NAMGISKAMM EKVMVAKSRN LEGTGTVICG TRYGNVMASR GSVIPLFVDQ IRAEKPITIT
DPHMTRFMMT LEDAVDLVLY AFNHGQNGDI FVQKAPAATI DTLARAITQM LDKEDHQINV
IGTRHGEKAF EALLSREEKA CAEDLGDYFR VPADQRDLNY EKYIEDGNTK VVEYEDYNSH
NTTRLDVEVL ITGANGFVAK NLIQYLSEKE NIEILKYYRD STEQELEQLV LDAEWIIHLA
GVNRPKNDGE FIEGNVSLTE KICDILRENK KKTPIILSSS IQAERDNVYG QSKLGGEQAL
TKLNQENENP IYISRMVNIF GKWSKPNYNS AVATFCYNIA NDLPIQINDP NALIRLVYID
DVVETIWNIL NQKYPANEPF EIKPEYQITV GRLAETIYGF KGSRESLITD RVGVGLTRAL
YSTYLSFFSP KQFDYTVTKY GDDRGVFVEM LKTPDAGQFS YFTAHPGITR GGHYHHTKTE
KFLVIKGQAL FKFKHVITGE FYQLETSGEE PRIVETVPGW THDITNIGDD EMVVMLWANE
IFDRSKPDTY AMPLSN
//
