ID A0A7S8CB49_9BACI Unreviewed; 593 AA.
AC A0A7S8CB49;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 18-JUN-2025, entry version 20.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=G8O30_07045 {ECO:0000313|EMBL:QPC46735.1};
OS Mangrovibacillus cuniculi.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Mangrovibacillus.
OX NCBI_TaxID=2593652 {ECO:0000313|EMBL:QPC46735.1, ECO:0000313|Proteomes:UP000593626};
RN [1] {ECO:0000313|EMBL:QPC46735.1, ECO:0000313|Proteomes:UP000593626}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R1DC41 {ECO:0000313|EMBL:QPC46735.1,
RC ECO:0000313|Proteomes:UP000593626};
RA Sefrji F., Michoud G., Merlino G., Daffonchio D.;
RT "Genome sequence of 2 isolates from Red Sea Mangroves.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
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DR EMBL; CP049742; QPC46735.1; -; Genomic_DNA.
DR RefSeq; WP_239674269.1; NZ_CP049742.1.
DR AlphaFoldDB; A0A7S8CB49; -.
DR KEGG; mcui:G8O30_07045; -.
DR Proteomes; UP000593626; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:TreeGrafter.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0030295; F:protein kinase activator activity; IEA:TreeGrafter.
DR GO; GO:0007234; P:osmosensory signaling via phosphorelay pathway; IEA:TreeGrafter.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR FunFam; 3.30.565.10:FF:000006; Sensor histidine kinase WalK; 1.
DR FunFam; 1.10.287.130:FF:000001; Two-component sensor histidine kinase; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P_dom.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR041328; HisK_sensor.
DR InterPro; IPR052545; Light-responsive_reg.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR42878:SF3; HISTIDINE PROTEIN KINASE SAES; 1.
DR PANTHER; PTHR42878; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF18698; HisK_sensor; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF08448; PAS_4; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:QPC46735.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000593626};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..248
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 371..588
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 593 AA; 66537 MW; 9B62EC3681AA7E22 CRC64;
MKIWKSVVGK LWITILLLVS FVLFVLTILL LEFFQNYHVD EVEKELLRSA EKVSTILAEH
SELMYGLEIV DEIIDSPSQV IITDAEGNRL HATKSEELVV SNKDIASSPM LLKVFTGETV
TQEIRVGTLS GSRDRYENVI VSGTPYKHTD GKTYGVFVFQ SLQVLKQTTQ QTTQVILLAA
GIAIILTTIF AFFLSTRITA PLRKMREAAF EVSKGNFSSK VPILTNDEIG ELATAFNQMG
RQITYHIHAL NQEKEQLFSI LSSMADGVIT INRDGTVLIT NPPADRFLEQ AHYEKEGEAF
QAVPKDVVLL FSKVMETEKE QFTEMTVQGR TYMIVITPLY NEQSVRGAVA VLRDMTEERK
HDVLRKDFIA NVSHELRTPI SMLQGYSEAI MDDIAGTDEE KKEFAKIIYD ESLRMGRLVN
DLLDLARMEA GYQSISKDDV PISSFIKRIS LKFQGVARES SVQLSTENEL LGSIWADPDR
LEQVFTNLID NALRHTPEGG NVKIKSSRKG SNAIFEVQDS GQGIHEDDLP FVFERFYKAD
KARTRGKSGT GLGLAIVKNI INAHGGSIEV RSKLGQGTTF IIELPIKMQN ERR
//
