ID A0A7W3YDW2_9GAMM Unreviewed; 795 AA.
AC A0A7W3YDW2;
DT 02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 1.
DT 18-JUN-2025, entry version 17.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00044770};
DE EC=2.4.99.28 {ECO:0000256|ARBA:ARBA00044770};
GN Name=pbpC {ECO:0000313|EMBL:MBB1087571.1};
GN ORFNames=H4F99_03605 {ECO:0000313|EMBL:MBB1087571.1};
OS Marilutibacter penaei.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Lysobacterales; Lysobacteraceae; Marilutibacter.
OX NCBI_TaxID=2759900 {ECO:0000313|EMBL:MBB1087571.1, ECO:0000313|Proteomes:UP000552587};
RN [1] {ECO:0000313|EMBL:MBB1087571.1, ECO:0000313|Proteomes:UP000552587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SG-8 {ECO:0000313|EMBL:MBB1087571.1,
RC ECO:0000313|Proteomes:UP000552587};
RA Xu S., Li A.;
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.99.28;
CC Evidence={ECO:0000256|ARBA:ARBA00049902};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the transpeptidase
CC family. {ECO:0000256|ARBA:ARBA00007090}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC glycosyltransferase 51 family. {ECO:0000256|ARBA:ARBA00007739}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBB1087571.1}.
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DR EMBL; JACHTE010000002; MBB1087571.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7W3YDW2; -.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000552587; Unassembled WGS sequence.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:TreeGrafter.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR FunFam; 3.40.710.10:FF:000021; Penicillin-binding protein 1C; 1.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR050396; Glycosyltr_51/Transpeptidase.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000552587};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 70..239
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 317..534
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 711..791
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 795 AA; 86245 MW; A4FEB61DBA35D14A CRC64;
MAPMRPRSGA ASGGRARRGG LWCALVVMLL VDAGMLADLA FPLPLPDPRE GGTVVVASNG
APLRMFADRE GIWRHPVDPG QVSGLYLQAL LAYEDRHFRH HPGINPVALA RAGWQWLREG
RVVSGGSTLT MQVARILDPP KGSSRTASAK LRQMARALQI EAHLSKDEIL SLYLNRAPFG
GTIEGVEAAS WAYLGKPASR LSRAEAALLV VLPQAPSRWR PDREPARARQ ARDKVLARMA
DLGVWTRAEV EDARIEPVVA RDLHAPRHAA LLARRLKAAD PDRRRIESTL DFDLQRTLES
RVASYFSALP ARTSAALLVI DNASMEARAY VGSVAFADRQ RLGHVDMVRA WRSPGSTLKP
FLYGLAIDDG LIHSGSLLVD APQSFGDYRP GNFDAAFRGP VTTATALQLS LNVPAVDVLD
RVGPARFAAR LAHAGIDLRW PRGSRPNLSM ILGGTGARLE DLVGAYAALN REGRAGRVRY
RPDDTLDDRR LLSPEAAWIV RRMLEDHPRP GSADSFDESG RARVAWKTGT SYGFRDAWAL
GGTRSHTVGV WVGRPDGTSL PGQYGAITAL PLLFEIIDAL PMHASDARPA PPPAGVARHK
VCWPLGQLYE ATVPGACRRR IDAWTLADVV PPTLPERDAR LWSAGLARFD VDAVSGERLS
ANCDADHPRR AAVVARWPAL ATPWLSVAER RAARLPPLAD DCLDDGREGL AELRIDGLHP
RAILAAAPGA SSGLRLRVRA LGSDARIRWL LDGRLVGESV GSARFEHDFG NPGLHTLTAL
AETGAWASVE FRVLK
//
