ID A0A7W5AE52_9ACTN Unreviewed; 593 AA.
AC A0A7W5AE52;
DT 02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=FHR83_002185 {ECO:0000313|EMBL:MBB3094533.1};
OS Actinoplanes campanulatus.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=113559 {ECO:0000313|EMBL:MBB3094533.1, ECO:0000313|Proteomes:UP000590749};
RN [1] {ECO:0000313|EMBL:MBB3094533.1, ECO:0000313|Proteomes:UP000590749}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 3287 {ECO:0000313|EMBL:MBB3094533.1,
RC ECO:0000313|Proteomes:UP000590749};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBB3094533.1}.
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DR EMBL; JACHXF010000003; MBB3094533.1; -; Genomic_DNA.
DR RefSeq; WP_183218795.1; NZ_BMPW01000008.1.
DR AlphaFoldDB; A0A7W5AE52; -.
DR Proteomes; UP000590749; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:MBB3094533.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000590749}.
FT DOMAIN 1..166
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 593 AA; 62452 MW; 690DF09FB90B27CF CRC64;
MFVIATAGHV DHGKSTLVRA LTGMEPDRWA EERRRGMTID LGFAWTSLAD DEMTAFVDVP
GHQRFVTNML AGVGPVTAVM FVVAADEGWR QQSAEHLAAL HALDVRHGVL AVTRSDLADP
GPAIAQARER LDGTGLAGIP AVAVSAVTGQ GLAALRDTLR DLTRALPAPA PGPARLWVDR
SFSVRGSGTV VTGTLASGTV TVGDDLLLYP SGRTVQVRGL QSLKTDVDRA GAVSRLAVNL
RGLKTDEVRR GHALVQPGAF APVTSMDVRL VRAADRLPAQ LTLHLGSAAV AVRVRMLGPS
AARLTPATPL PLHVGERGLL RDPGARHVVA GFVVLDTMPP GLHARGDARR RATALAGMRD
RPTVAEEVGR RGAVRREALV MAGVLAPGDA DPDGVVTAGG WLVDPVVWKQ WTAALHRVVD
EWAAANPLSP GIAPDAAARR AGITDARLVG ALAAEAGLVL DVSGVHGRDT GIRFPAPIRR
ALDEICAGLR DAPFAAPGAE DLARLGLSRR HLAAAVTAGV LIRITDGVYL LPGAPAEALR
RVAALPQPFT VSQARAAWDT SRRVAVPLLE HLDRQGATRR LDTARRILTK ESR
//
