ID A0A7W6P0B6_9HYPH Unreviewed; 334 AA.
AC A0A7W6P0B6;
DT 02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 1.
DT 18-JUN-2025, entry version 15.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|ARBA:ARBA00019465};
DE EC=1.1.1.169 {ECO:0000256|ARBA:ARBA00013014};
DE AltName: Full=Ketopantoate reductase {ECO:0000256|ARBA:ARBA00032024};
GN ORFNames=GGQ66_001142 {ECO:0000313|EMBL:MBB4102607.1};
OS Allorhizobium borbori.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Hyphomicrobiales; Rhizobiaceae; Rhizobium/Agrobacterium group;
OC Allorhizobium.
OX NCBI_TaxID=485907 {ECO:0000313|EMBL:MBB4102607.1, ECO:0000313|Proteomes:UP000584824};
RN [1] {ECO:0000313|EMBL:MBB4102607.1, ECO:0000313|Proteomes:UP000584824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26385 {ECO:0000313|EMBL:MBB4102607.1,
RC ECO:0000313|Proteomes:UP000584824};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+);
CC Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.169; Evidence={ECO:0000256|ARBA:ARBA00048793};
CC -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-
CC pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004994}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBB4102607.1}.
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DR EMBL; JACIDU010000003; MBB4102607.1; -; Genomic_DNA.
DR RefSeq; WP_183790327.1; NZ_JACIDU010000003.1.
DR AlphaFoldDB; A0A7W6P0B6; -.
DR UniPathway; UPA00028; UER00004.
DR Proteomes; UP000584824; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR051402; KPR-Related.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; NF005089; PRK06522.1-4; 1.
DR PANTHER; PTHR21708:SF45; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:MBB4102607.1};
KW Pantothenate biosynthesis {ECO:0000256|ARBA:ARBA00022655};
KW Reference proteome {ECO:0000313|Proteomes:UP000584824}.
FT DOMAIN 6..179
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 206..322
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 334 AA; 35523 MW; 83EDEB61E538B788 CRC64;
MTFRNICIYG AGALGGAIAA KFSSGLAGEA EVSAVARGAH LARMREKGLT IIEDGVDEPK
VHRLTATDDP RELGAQDLVI TGLKGHQLAA AAEGLATLLK PETRVVMILN GVPWWYFHGD
PDPAHAGTQL EALDPGGTLW RLIGPERIIG CVAYQGGEVV EPGTIHLYHK KRLILGEPDG
SASADIETVA ALLNRCGLVG EATTAIRAEI WTKLMNNAAF NPVSALTRAT MAPLLSDPAI
VATMGDIMRE VKAVAAAFGV NLAIDVDQRL EDSRAIPDVR TSMLQDLLAG RPLEIVSVLG
MVIELARMAS VPVPTCRTTY ALTVRLDEEN RRTA
//
