ID A0A7Y7B3C0_STRMO Unreviewed; 659 AA.
AC A0A7Y7B3C0;
DT 02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 1.
DT 28-JAN-2026, entry version 14.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203,
GN ECO:0000313|EMBL:NVK78259.1};
GN ORFNames=HG542_11350 {ECO:0000313|EMBL:NVK78259.1};
OS Streptomyces morookaense (Streptoverticillium morookaense).
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1970 {ECO:0000313|EMBL:NVK78259.1, ECO:0000313|Proteomes:UP000587462};
RN [1] {ECO:0000313|EMBL:NVK78259.1, ECO:0000313|Proteomes:UP000587462}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40503 {ECO:0000313|EMBL:NVK78259.1,
RC ECO:0000313|Proteomes:UP000587462};
RA Qi J., Gao J.-M.;
RT "Draft Genome Sequence of Streptomyces morookaense DSM 40503, an 8-
RT azaguanine-producing strain.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NVK78259.1}.
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DR EMBL; JABBXF010000021; NVK78259.1; -; Genomic_DNA.
DR RefSeq; WP_171080223.1; NZ_BNBU01000005.1.
DR AlphaFoldDB; A0A7Y7B3C0; -.
DR Proteomes; UP000587462; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR FunFam; 3.30.420.340:FF:000003; UvrABC system protein C; 1.
DR FunFam; 3.40.1440.10:FF:000001; UvrABC system protein C; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR050066; UvrABC_protein_C.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; NF001824; PRK00558.1-5; 1.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF22920; UvrC_RNaseH; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203}; Reference proteome {ECO:0000313|Proteomes:UP000587462};
KW SOS response {ECO:0000256|ARBA:ARBA00023236, ECO:0000256|HAMAP-
KW Rule:MF_00203}.
FT DOMAIN 16..95
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 208..243
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 259..517
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
FT REGION 470..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 211..247
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 481..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 659 AA; 73623 MW; D4F3DEA3DEC8ABEF CRC64;
MADPSSYRPK PGQIPDSPGV YRFRDEHGRV IYVGKAKSLR QRLSSYFQDL AGLHPRTRTM
VTTAASVEWT VVSTEVEALQ LEYSWIKEYD PRFNVKYRDD KSYPSLAVTL NEEFPRVQVM
RGPKKKGVRY FGPYAHAWAI RETVDLMLRV FPVRTCSAGV FKRSHQIGRP CLLGYIGKCS
APCVGRVSPE EHRELAEEFC DFMAGRTGAY IRRLERQMHE AAEEMEYEKA ARLRDDIEAL
KRAMEKNAVV LADATDADLI AVAEDELEAA VQIFHVRGGR VRGQRGWVTD KVEAVDTAGL
VEHALQQLYG EERGDAVPKE VLVPALPEPV GPVQQWLTER RGAAVSLRIP QRGDKKDLMA
TVQRNAQQAL VLHKTRRASD LTTRSRALEE IAGALGLDSA PLRIECFDIS HLQGQDVVAS
MVVFEDGLAR KSEYRRFQIK GFEGQDDVRS MHEVIGRRFR RYLQEKQKEG EWSEENAVEA
EDSRLDDDGR PKRFAYPPQL VVVDGGQPQV AAARRALDEL GVDDVAVCGL AKRLEEVWLP
GEDDPVVLPR TSEGLYLLQR VRDEAHRFAI SYQRGKRSKT MKAGALDAVP GLGETRRKAL
LKHFGSVKRL RAATVEELCA APGIGRKTAE TIAAALAAAP APAPAVNMAT GEIMDDTEE
//
