ID A0A7Y9H3X9_9ACTN Unreviewed; 324 AA.
AC A0A7Y9H3X9;
DT 02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 1.
DT 02-APR-2025, entry version 13.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:NYE37188.1};
DE EC=1.1.1.169 {ECO:0000313|EMBL:NYE37188.1};
GN ORFNames=F4692_002321 {ECO:0000313|EMBL:NYE37188.1};
OS Nocardioides cavernae.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=1921566 {ECO:0000313|EMBL:NYE37188.1, ECO:0000313|Proteomes:UP000549911};
RN [1] {ECO:0000313|EMBL:NYE37188.1, ECO:0000313|Proteomes:UP000549911}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AT2.17 {ECO:0000313|EMBL:NYE37188.1,
RC ECO:0000313|Proteomes:UP000549911};
RA Partida-Martinez L., Huntemann M., Clum A., Wang J., Palaniappan K.,
RA Ritter S., Chen I.-M., Stamatis D., Reddy T., O'Malley R., Daum C.,
RA Shapiro N., Ivanova N., Kyrpides N., Woyke T.;
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:NYE37188.1, ECO:0000313|Proteomes:UP000549911}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AT2.17 {ECO:0000313|EMBL:NYE37188.1,
RC ECO:0000313|Proteomes:UP000549911};
RA Partida-Martinez L.P.;
RT "The Agave Microbiome: Exploring the role of microbial communities in plant
RT adaptations to desert environments.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NYE37188.1}.
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DR EMBL; JACCBW010000002; NYE37188.1; -; Genomic_DNA.
DR RefSeq; WP_179619760.1; NZ_JACCBW010000002.1.
DR AlphaFoldDB; A0A7Y9H3X9; -.
DR Proteomes; UP000549911; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:TreeGrafter.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR050838; Ketopantoate_reductase.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:NYE37188.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000549911}.
FT DOMAIN 4..138
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 201..299
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 324 AA; 33004 MW; 5D6BB094333FE4C9 CRC64;
MRHVVYGAGA VGGVIGGHLH LAGSPVTLVA RGEHLAAIRS GGLVLDTGDG RHRIDAPATD
TAADVAWTDD TVVLLAVKSH QAAAALADLR AHAPADTPVV CATNGIATET ATLRSFARTY
ALCVMLPASH LEPGVVVASC HPTPAILDVG RIPGGTDAVT AAVSADLRAA GIDSVERDDI
MAMKRRKLVL NLGNGVDASF AEGEAADELA ARAQAEGEQV LAAAGVSVVT AEEDRARRGS
ILQRRPDLER RGGSTWQSLS RGTGDSEIDY LAGEVVLQGR LLGIPTPVNE AVVAATRALA
YAGGAPRSLD AGKVLAALGP PTGE
//
