ID A0A7Y9ZCG2_9MICO Unreviewed; 903 AA.
AC A0A7Y9ZCG2;
DT 02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE SubName: Full=Calcium-translocating P-type ATPase {ECO:0000313|EMBL:NYI41663.1};
GN ORFNames=BKA03_001782 {ECO:0000313|EMBL:NYI41663.1};
OS Demequina lutea.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micrococcales;
OC Demequinaceae; Demequina.
OX NCBI_TaxID=431489 {ECO:0000313|EMBL:NYI41663.1, ECO:0000313|Proteomes:UP000547973};
RN [1] {ECO:0000313|EMBL:NYI41663.1, ECO:0000313|Proteomes:UP000547973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19970 {ECO:0000313|EMBL:NYI41663.1,
RC ECO:0000313|Proteomes:UP000547973};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00049360};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IIA subfamily. {ECO:0000256|ARBA:ARBA00005675}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NYI41663.1}.
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DR EMBL; JACBZO010000001; NYI41663.1; -; Genomic_DNA.
DR RefSeq; WP_218856016.1; NZ_JACBZO010000001.1.
DR AlphaFoldDB; A0A7Y9ZCG2; -.
DR Proteomes; UP000547973; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005391; F:P-type sodium:potassium-exchanging transporter activity; IEA:TreeGrafter.
DR GO; GO:0030007; P:intracellular potassium ion homeostasis; IEA:TreeGrafter.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:TreeGrafter.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:TreeGrafter.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:TreeGrafter.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:TreeGrafter.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR059000; ATPase_P-type_domA.
DR InterPro; IPR050510; Cation_transp_ATPase_P-type.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR43294:SF21; CATION TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000547973};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 770..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 809..826
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 842..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 874..891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..78
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
SQ SEQUENCE 903 AA; 93842 MW; DD7B7B133E401CEC CRC64;
MAADVSLLTA DEVVRLAGAD TTFGLSSEEA AIRLAADGPN SLTERKRVSW QRRLLLQFAD
PLVYLLLAAF AVTITVWLVD GREGVPYDSI VIAIVVIANA ILGLVQERRS ESAVAALQHM
SAASALVMRN GNAQRIPAAG VVRGDLLLLA EGDAVAADAR LVTSELRVAE AVLTGESAPA
QKRTEPLEAH AEVADRTCMV FAGTAVSRGT GRAIVTGIGM DTETGRIARM LGETEPDPTP
LQREIAHLSR TLGIAVVVIA VVVIGTVWLT SDVTTLSQVV SILLLGVALA VAAVPEGLPA
ILSVVLSLGV RRMADHHAIV KDLSSVETLG SASVICTDKT GTLTLNRMTL MTVATAHGLM
DIADAAASHP GASPELTALI RSSCVANDAV ANPDGGEING DPTDVAFLDA ERLMSLGGSG
NASENRVAGV PFSAARARMS AATQDASGER TLHVKGGPEV LLSLSTRMLV GETQVPLDAA
ARERVLANTA TLAGRGMRTL GVAFRTLSDG EACDEAAEQD LTFIGVAGLV DPSRPEARDA
VADAQLAGIR IVMITGDHPA TALAIARDLG IAADETVLTG AELASMSDAE LGEAVANCAV
FARVAPELKL RIVDAFQARG EVVAMTGDGV NDAPALRSAD IGVAMGLGGT EVAREASSMI
LADDNFTTIV TAVREGRGIL DNIKRFLRYL LASNAGEVLA VFFGVAGAGV LGLSGHGEVV
AVPLLATQIL WINLLTDLGP ALAIGAEPYA ADLMSRQPRK PTDRLIDGRM WRGVALTGIV
MAVVTLVALD AFLPGGLIEG SESLDTARTA AFTVLVLTQL MNAFSARSET VSVVKNLATN
RWLWGAVTLS ALLQVAVVHV PLLNRAFSTA PLSVSQWATC VALSAVVPLV TELRKWGLRR
RGV
//
