ID   A0A803MK33_CHEQI        Unreviewed;      1120 AA.
AC   A0A803MK33;
DT   02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 1.
DT   05-FEB-2025, entry version 13.
DE   RecName: Full=Tower domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Chenopodium quinoa (Quinoa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Caryophyllales; Chenopodiaceae; Chenopodioideae; Atripliceae; Chenopodium.
OX   NCBI_TaxID=63459 {ECO:0000313|EnsemblPlants:AUR62030766-RA:cds, ECO:0000313|Proteomes:UP000596660};
RN   [1] {ECO:0000313|EnsemblPlants:AUR62030766-RA:cds}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. PI 614886 {ECO:0000313|EnsemblPlants:AUR62030766-RA:cds};
RX   PubMed=28178233; DOI=10.1038/nature21370;
RA   Jarvis D.E., Ho Y.S., Lightfoot D.J., Schmoeckel S.M., Li B., Borm T.J.A.,
RA   Ohyanagi H., Mineta K., Michell C.T., Saber N., Kharbatia N.M.,
RA   Rupper R.R., Sharp A.R., Dally N., Boughton B.A., Woo Y.H., Gao G.,
RA   Schijlen E.G.W.M., Guo X., Momin A.A., Negrao S., Al-Babili S., Gehring C.,
RA   Roessner U., Jung C., Murphy K., Arold S.T., Gojobori T.,
RA   van der Linden C.G., van Loo E.N., Jellen E.N., Maughan P.J., Tester M.;
RT   "The genome of Chenopodium quinoa.";
RL   Nature 542:307-312(2017).
RN   [2] {ECO:0000313|EnsemblPlants:AUR62030766-RA:cds}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (MAR-2021) to UniProtKB.
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DR   AlphaFoldDB; A0A803MK33; -.
DR   EnsemblPlants; AUR62030766-RA; AUR62030766-RA:cds; AUR62030766.
DR   Gramene; AUR62030766-RA; AUR62030766-RA:cds; AUR62030766.
DR   OMA; MMELYNQ; -.
DR   Proteomes; UP000596660; Unplaced.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:TreeGrafter.
DR   CDD; cd04493; BRCA2DBD_OB1; 1.
DR   FunFam; 2.40.50.140:FF:000262; Protein BREAST CANCER SUSCEPTIBILITY 2 homolog B; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 4.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015252; BRCA2_hlx.
DR   InterPro; IPR036315; BRCA2_hlx_sf.
DR   InterPro; IPR015187; BRCA2_OB_1.
DR   InterPro; IPR002093; BRCA2_repeat.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   Pfam; PF09169; BRCA-2_helical; 1.
DR   Pfam; PF09103; BRCA-2_OB1; 1.
DR   Pfam; PF00634; BRCA2; 2.
DR   SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR   SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   PROSITE; PS50138; BRCA2_REPEAT; 2.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000596660};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          518..591
FT                   /note="Breast cancer type 2 susceptibility protein helical"
FT                   /evidence="ECO:0000259|Pfam:PF09169"
FT   DOMAIN          595..711
FT                   /note="BRCA2 OB1"
FT                   /evidence="ECO:0000259|Pfam:PF09103"
FT   REGION          149..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1120 AA;  124275 MW;  724E1D243EA8234C CRC64;
     MSTWQIFSDA GDNFRWEVSP SHQPSHQQTN HHCSTPPPSL PSFHDVLLQG CSKILEDCDN
     RNVVDDDIPM FRTGSGSSVV LKKSSIAKAS SVLGDDFIDN FDTEQPCFKG NGFSTPNSMF
     QTGSGKKVNV SSSGLLRARA LLSVEESNDD FSTQGSEPAK KKFRGVDTSA FEKHSSSGKR
     KFGISSMGAN KDMHFSKSPF HLKSDSSGAE FGDEDFAKLI RPEMSDSICK PPAIKFNTAG
     GRFISVSRDA LQRARNLLSD PEMDSPSHEG DVGASMFSFI KAGDSDGSFF NKENKTDYSH
     KSEQNPKIFV SPMKSSSTMK PLLETKSENL ISGTNLMRKF DAEESNCKSN GKLSCPTNSL
     QGKSNVPDPV LQPSMANGAG PGFHRFSKSS GVPLSDISNT IGIDSKVSAI KKGTTTELKR
     LGKRSSVSPF KMPRNSKFIT PLNSNLSSIP DGLSSRESEA SNCRKRVCTR YPFQNSRLYV
     KEFFEKPPTY PELLDHIPEE VRQITPRTSE KYTFVDGSQR FGVENFYHLL VQSGASVQHA
     SKEWVTNHFK WIVWKLASYE RCYSSKSMKK FLTISDVLEE LKYRYEREVN HGQRSAIKRI
     LEGDASPSSM LVLCVSEIED PSTSMADKSS NSRIELTDGW YSVCAQLDLV LSKQLDAGKL
     FVGQKLRICG AGLIGWNGPV SPLKASPLIS LMLHINGTYR ASWHERLGLC RGMCAPLAFR
     CIKDNGGLIP RTLVGVTRMY PVLYRERLKS GGYIVRSEKL EASLTQLYNR RRSNIIEGLT
     SDFQRGLVGS CTEDDYDNEG AKIMKMLESA AEPELLMAEM SSEQLASFSK YRATIDETRQ
     GDLQRLIEKA LEDAGLSARD VTPFMRVRVV GLKSRGQYKG EVQREGLITI WNPTEQQKLE
     LVEGQAYAIS GLIPSHSDLS TLYLQARGSS TKWKPLTTKE KESFGPFFNP RKPVSLSRMG
     EVPLSSEFDT AMLVLHVGLE YISGKQKKQW VFVTDGSLCE TEVSTFSLLA INFCSPCGDD
     DSLSLVNYNL VGSIIGFCNL VKRTKDHVNL MWVAEATENS TYYLKYNHPY CSHLKDAFGL
     VKKWQQSASS TIEKLREKIL HIVGGPKGPI GLVVNTNAHK
//