ID A0A803TJB7_ANOCA Unreviewed; 2788 AA.
AC A0A803TJB7;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 08-OCT-2025, entry version 20.
DE SubName: Full=LPS responsive beige-like anchor protein {ECO:0000313|Ensembl:ENSACAP00000035307.1};
GN Name=LRBA {ECO:0000313|Ensembl:ENSACAP00000035307.1};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000035307.1, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000035307.1, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000035307.1,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000035307.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR Ensembl; ENSACAT00000041079.1; ENSACAP00000035307.1; ENSACAG00000003023.4.
DR GeneTree; ENSGT00940000154778; -.
DR Proteomes; UP000001646; Chromosome 5.
DR Bgee; ENSACAG00000003023; Expressed in forelimb bud and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-ARBA.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR FunFam; 2.130.10.10:FF:000886; lipopolysaccharide-responsive and beige-like anchor protein isoform X1; 1.
DR FunFam; 1.10.1540.10:FF:000001; neurobeachin isoform X1; 1.
DR FunFam; 2.30.29.30:FF:000059; neurobeachin isoform X1; 1.
DR FunFam; 2.60.120.200:FF:000010; neurobeachin isoform X2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR050865; BEACH_Domain.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF64; LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 2.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 1999..2107
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2126..2415
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2700..2733
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..1016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1516..1591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1606..1625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1715..1748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..29
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1168..1178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1179..1190
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1524..1534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1560..1578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1737..1748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2788 AA; 311486 MW; 594281BF135A6581 CRC64;
MASEDKQVSS PRPTGDDGGG GLGGGGGKEG ISSEMESNMQ PLNPGVPIRG IRMKFAVLSG
LVEVGEVSNR DIVDTVFNLL VGGHFDLEMN FIIQEGESIT CMVDLLDKCD VTCQAEVWSM
FTAILKKSIR NLQICTEVGL VEQVLERIDQ ADNMIADLLV DMLGVLASYS VTVRELKLYF
SRLQGDKGKW PPHAGKLLSV LKHMPQKYGP DAFFNFPGKS AAAIALPPIA KWPYQNGFTF
HTWLRMDPVN NINVDKDKPY LYCFRTSKGL GYSAHFVGGC LVVTSIKSKG KGFQHCVKFD
FKPQKWYMVT IVHIYNRWKN SELRCYVNGE LASYGEITWF VNTSDTFDKC FLGSSETADA
NRVFCGQMTA VYLFSEALNA AQIFAIYQLG LGYKGTFKFK GESDLFLADH HKQLLYDGKL
SNAVAFTYNP RATDAQLCLE SSPKDNPSIF VHSPHALMLQ DVKAVVTHSI QSAMHSIGGV
QVLFPLFAQL DYRQYSLDQP DTTVCSILLA FIMELLKKSI AMQEQMLSCK GFLVIGYSLE
KSSKAHVSRA VLELCLAFAK YLSNLHHGVP LLKQLCDHIL LNPAIWIHTP AKIQLTLYTY
LSTEFIGTAN IYNAIRRVGT VLLAMHTLKY YYWVVNPQDR SGIIPKGLDG PRPNQKEILS
LRAFLLMFVK QLVMKDDNLM DVLQLLVALM SEHPSSMIPA FDQRNGLRVI YKLLASKSEG
IRVQALKVMG YFLKHLAPKR KAEIMLGHGL FSLLAERLTL QTSLITMTTY NVLFEILIEQ
ICTQVIHKQH PDPDSTVKIQ NPQVLKVIAT LLRHSPQCPE TIEVHRVFLS DMIKLFNSSR
DNRRSLLQCS VWQEWMLSLC YFNPKTSDEL KITEMVYAIF RILLYHAIKY EWGGWRVWVD
TLAITHSKVS FEMHKENLSQ MFREYQDKED EDCGVGPSTI IRTVSGTSRE VEVAARQQHL
EIKEIDISRN DVGCDDARNS TLRGDEGPSD FAEPTNSKVN EENGQGSSDL NADPHLECSL
PPETIQQNLG VTSTGTVETN HKEEIVTVSE AQTPSENTDG ETLESPEILE KLTPEVEEEE
EDFVDLKEES NLPFTSEESV PKTNEHTTEE IQIAQAIPPL KEPILTDSES KSVVASVERQ
QDPESLPETS ASEVSDGKVQ PDSNAVEKIS EENTDHPQNK TTTDNTPPNT SEIVASEKKI
AKLDVSSVAS DTERLELKSN TTLEVNQPVR SIPETSRQQD PSGQSIGAVS DGQRRDSRST
MFRIPEFRWS QMHQRLLTDL LFSIETDVQM WRSHSTKTVM DFVNSSDNVI FVHNTIHLIS
QVMDNMIMAC GGILPLLSAA TSATHELENI EPTQGLSIEA SVAFLQRLIS LVDVLIFASS
LGFTEIESEK NMSSGGILRQ CLRLVCAVAV RNCLECQQQH AVMKPSGENV KCQKTAQSLI
AAGKSGAKSP IDIVTGGISP IRDIDRLLQD MDINRLRAVV FRDIEDSKQA QFLALAVVYF
ISVLMVSKYR DILEPQDERR QRQSRGVLSR NLQEAESPPG AITTLTPVPA EESEIVASVQ
RRDSGIEEEA HSSLEHNSEV VTEEAQSVSA GPDAVSEVLC TLSSEVNKSQ ESRSELQSEV
DSNTSSLQAA KNVNVKDILR SLVSAPAGGA IVDPAILPPT FLGVLGDGVA EQPVQFQSFD
RSVVVAPKKS VASTTAAVNM PTNAVSVVSS MDSAQTPDVI GGSPGSGSSN SRLPSVPTVS
SVPEDSASNM SITERLEHAL EKAAPLLREI FVDFAPFLSR TLLGSHGQEL LIEGTSLVCM
KSSSSVVELV MLLCSQEWQN SIQKNAGLAF IELVNEGRLL SQTMKDHLVR VANEAEFILS
RQRAEDIHRH AEFESLCAQY SADKREDEKM CDHLIRAAKY RDHVTVNRFL FRPREFWRLD
YWEDDLRRRR RFVRNPLGST HPEATLKAAI DHAPDEDVLV KGKQSIRSQA LGNQNSESEI
LLEGDDDTLS SIEEKELENL TGPVSLSTPA QLVAPCVVVK GTISITASEL YFEVDEEESS
FKKIDPKILA YTEGLHGKWL FSDMRSIFSR RYLLQNTALE IFMANRVSVM FNFPDPATVK
KVVNCLPRVG IGTSFGLPQT RRISMATPRQ ILKASNMTQR WQHREISNFE YLIFLNTVAG
RTYNDLNQYP VFPWVITNYE SEELDLTLPS NFRDLSKPVG ALNPKRGAFF AERYETWEDE
QVPKFHYGTH YSTASFTLTW LLRIEPFTTF FLNLQGGKFD HADRTFSSIS RAWRNCQRDT
SDIKELIPEF YYLPEIFVNS NNYNLGVMDD GTVVSDVELP PWAKTPEEFV RLNRLALESE
FVSCQLHQWI DLIFGYKQQG PEAVRSLNVF YYLTYEGAVN LNSITDSVLR EAVEAQIRSF
GQTPSQLLIE PHPPRSSAMQ VSPLMFTDQA QQDVIMVLKF PSNSPVTHVA ANTQPALANP
AVITVTANRL FAVNKWHNLP AHQGAVQDQP YQLPVEIDPL IASNTSMHRR QITDLLDQSI
QVHSQCFVIT SDNRYILVCG FWDKSFRVYS TDTGKLIQVV FGHWDVVTCL ARSESYIGGN
CYILSGSRDA TLLLWYWNGK TNSIGDWPGD SATPRAILTG HDYEITCIAI CAELGLAISG
SKEGPCLIHS MNGDLLRTLE PPENCLKAKL IQASREGHCV IYYDNGHFCV FSVNGKLQAT
METDDNIRAI QLSRDGQYLL TGGDNGVIMV WQVCDLKQLF AYPGCDAGIR SMALSHDQRC
IMTGMASGSI VLFYNDFNRW HHEYQTRY
//
