ID A0A803XK71_MELGA Unreviewed; 934 AA.
AC A0A803XK71;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 18-JUN-2025, entry version 20.
DE RecName: Full=Squamous cell carcinoma antigen recognized by T-cells 3 {ECO:0000256|ARBA:ARBA00069395};
GN Name=SART3 {ECO:0000313|Ensembl:ENSMGAP00000019917.1};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000019917.1, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000019917.1, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000019917.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}. Nucleus, Cajal body
CC {ECO:0000256|ARBA:ARBA00004408}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
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DR AlphaFoldDB; A0A803XK71; -.
DR Ensembl; ENSMGAT00000030364.1; ENSMGAP00000019917.1; ENSMGAG00000005746.2.
DR GeneTree; ENSGT00900000141107; -.
DR InParanoid; A0A803XK71; -.
DR Proteomes; UP000001645; Chromosome 17.
DR Bgee; ENSMGAG00000005746; Expressed in bursa of Fabricius and 17 other cell types or tissues.
DR GO; GO:0015030; C:Cajal body; IEA:Ensembl.
DR GO; GO:0071001; C:U4/U6 snRNP; IEA:Ensembl.
DR GO; GO:0005691; C:U6atac snRNP; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR GO; GO:0030621; F:U4 snRNA binding; IEA:Ensembl.
DR GO; GO:0017070; F:U6 snRNA binding; IEA:Ensembl.
DR GO; GO:0030624; F:U6atac snRNA binding; IEA:Ensembl.
DR GO; GO:1990381; F:ubiquitin-specific protease binding; IEA:Ensembl.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0071425; P:hematopoietic stem cell proliferation; IEA:Ensembl.
DR GO; GO:0048872; P:homeostasis of number of cells; IEA:Ensembl.
DR GO; GO:0006334; P:nucleosome assembly; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR GO; GO:0051252; P:regulation of RNA metabolic process; IEA:Ensembl.
DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IEA:Ensembl.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:Ensembl.
DR CDD; cd12391; RRM1_SART3; 1.
DR CDD; cd12392; RRM2_SART3; 1.
DR FunFam; 1.25.40.10:FF:000081; squamous cell carcinoma antigen recognized by T-cells 3; 1.
DR FunFam; 1.25.40.10:FF:000098; Squamous cell carcinoma antigen recognized by T-cells 3; 1.
DR FunFam; 3.30.70.330:FF:000229; Squamous cell carcinoma antigen recognized by T-cells 3; 1.
DR FunFam; 3.30.70.330:FF:000271; squamous cell carcinoma antigen recognized by T-cells 3; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR008669; LSM_interact.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034217; SART3_RRM1.
DR InterPro; IPR034218; SART3_RRM2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR17204; PRE-MRNA PROCESSING PROTEIN PRP39-RELATED; 1.
DR PANTHER; PTHR17204:SF25; RRM DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF23241; HAT_PRP39_C; 1.
DR Pfam; PF23240; HAT_PRP39_N; 1.
DR Pfam; PF16605; LSM_int_assoc; 1.
DR Pfam; PF05391; Lsm_interact; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00386; HAT; 7.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 675..753
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 772..849
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 556..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..612
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..923
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 934 AA; 107331 MW; 628A2E5B42021596 CRC64;
AEEKAGRAVL VRVGVRRTGR HAEQQDEAQW AQTRTQEVPS EHEKELLHCE VDRALSRALS
INAFDYNCHL DLIKLLRQEG ELVKLRRARQ KMSELFPLTE EIWLDWLKDE IKMASEISER
EKVYELFERA VKDYICPEIW LEYAQYSIGG IGQEGGIEKV RSIFERALTA VGLHVTKGTA
LWEAYREFEN AILETAQVRL VCVPSPEQQQ MLCSQLERIH TLFRRQLGIP LLDMEASYAE
YEEWSEDPIP ETTIKNYKKA LQQLEKCKPY EEALLGAETP KLAEYQAYID FEMKAGDPAR
IQLIYERALA ENCLVPDLWA RYNQYLDRQL KVKELVLSAH DRAVRNCPWT VGLWIQYLLA
MERHGVDHCI ISEMFEKALN AGFIQATDYV EIWQAYLDYL RRRVDFTQDS SKELEELRSS
FARAVEYLKQ EVEERFSESG DPSCTIMQNW ARVEARLCNN MQKARELWDN IMTKGNAKYA
NMWLEYYNLE RAHGDTQHCR KALHRAVQCT SDYPEHVCEV LLTLERIEGT LEDWDAAVQK
TENRLARVNE QRAKAAEKEA ALARQEEEKA EQRKQSRAEK KASKKAKKNR IGEKRKADDD
DEGEWGQEEE EEQPSKRHKG DGDGLLLEED MELETGLFGR SGPEKPDLST NQKEKPSTSR
KDVPKVLHDS SKDNITVFVS NLSYNMTDPE VKLKELFESC GEVAQIRPVF SNKGTFRGYC
YVEFKDEKSA LQALGLDRNV VEGRPMFVSP CVDKNKNPDF KVFRYSTTLE KHKLFISGLP
FSCTKEELED ICKAHGNVKD IRLVTNRAGK PKGLAYVEFE NEAQASQAVL KMDGLTIKEH
IIKVAISNPP LRKLPDKAEA GRASQFAVPR QIYGARGKGR TQLSMMPRAL QRQSNPVAKA
ENGMVQNSPA ASSERTEEPK KMSNADFAKM LLNK
//
