ID   A0A812VLW1_SYMPI        Unreviewed;      1465 AA.
AC   A0A812VLW1;
DT   29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 1.
DT   28-JAN-2026, entry version 12.
DE   RecName: Full=5-hmdU DNA kinase helical domain-containing protein {ECO:0000259|Pfam:PF18723};
GN   ORFNames=SPIL2461_LOCUS17194 {ECO:0000313|EMBL:CAE7646638.1};
OS   Symbiodinium pilosum (Dinoflagellate).
OC   Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC   Symbiodinium.
OX   NCBI_TaxID=2952 {ECO:0000313|EMBL:CAE7646638.1, ECO:0000313|Proteomes:UP000649617};
RN   [1] {ECO:0000313|EMBL:CAE7646638.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Dougan E. K., Rhodes N., Thang M., Chan C.;
RL   Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CAE7646638.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CAJNIZ010043005; CAE7646638.1; -; Genomic_DNA.
DR   OrthoDB; 433132at2759; -.
DR   Proteomes; UP000649617; Unassembled WGS sequence.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:TreeGrafter.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR040684; HMUDK_hel.
DR   PANTHER; PTHR31616:SF0; GLUCAN 1,4-ALPHA-GLUCOSIDASE; 1.
DR   PANTHER; PTHR31616; TREHALASE; 1.
DR   Pfam; PF18723; HMUDK_hel; 1.
DR   SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000649617}.
FT   DOMAIN          379..713
FT                   /note="5-hmdU DNA kinase helical"
FT                   /evidence="ECO:0000259|Pfam:PF18723"
FT   REGION          96..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          328..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..170
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..221
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1465 AA;  162882 MW;  A72B604972DF436D CRC64;
     MDTFGGDPVF NCLVNNNSDK TGFYDVVLED FSKAEQFYED ASTILVTKLL SDKGDVVEIR
     DFAPRFVHYD RVFRPFQLIR LVRRLQAQKG KQSAGDLLIL TSPARSQAPA KRRRGKQSDG
     YLPTPYASGA PSDPMKRQRG KQSAGTLLMK RKRGKQSDSN LPTCSGSSSL PDAPTKRKRS
     KQGSGNLLMP QSARSDASTK RKPGRPCTKR PPSEQTKREV ANADAAVLSD VPADDPVRRL
     VKIGHKATAA QAAYFLLADA WNLEGRIDLA RLRENTGRRF IDASKVKISI RAKSTGGSVE
     EAARIARCCC RLAASGGTFE EVQRRKGQLL RGRKAAPENK ATPLPSSTSK VATREPVLEQ
     SKLPCRQQGH QVGQTPPESM LQHFYDMMNA RETIAKRRKA GVAGVQLYDN LPPDMAAYFK
     RWCCPNVRRR EDRTTKDLAR LADAHTRFKL CKSDAERDRL KSLLVLNFCV WRFMGGTLLF
     ARAIGFLTNW SDVEKDHIRR VITEAFRDGC AASLFSDAYE APQKIRKAFG RNCDDAKLEG
     LLYNRGLKAV VNREPALTYF TIHGRFRLID AVWRMAPEVV EAALPDQEGK CRWQKVANVL
     GRLPFFGRDE NNLREPTFFA KEIAQDLLDT PVFEGGRRSV SDLQSFSPAG PGAVLGLMLL
     YHLKERPLQG VAVPLMRAIL EEAPKYWQHP DSEPLELHDI QFMLCEVQKL FHSHNSQNSL
     RCYAGPTSAA TAFQASGAKL PWTQLVQDGL LLLQQRSASG VVPEEELQAF LIHWLGFTTY
     EQDEVLRHGD EVCLKVGTSF LTLEGFQAVD RLVRSSESND STLASFVLER RKGVGALQYG
     DEIWLRSNCG SHLGPVKKPS DGEQAKLGTN LSAPKFASER YDEGRLFVVE ADPARSSGPN
     EGDGKVTGAV RLRLQSPGAR LFLQADGNRC MVSSEADSSL VVLEHPPHRA EVTANLRACF
     VQAIADSLRE GVFKSYEAGT GKHMLSLAEL ESVIIVFGSD ESFTNSLSQV AMEFETKTTN
     YWKQWCSNLC LPVEFQQVLM RAAMTLAMNQ SEDCGGFLAT LSMGLPLGPF CPSTRDSRVC
     RLLDECLALP VLRDMGLLDL CKKFLGFAKE ICYREQVPQH VYNSWGALQD TKREYVPYLA
     GYRGMGEVHS GGMLLEDPAH DEESDAWPQA VIYGLLAISL VHAFFDVRLS QELCTPQLCE
     KLELYAQRAC SAFSHRCQMY KAYPTSDHVN RPMLPLGAGF FDDDLHFFVC EGLGDSHQSS
     DGLASVHTLT SVLCWAAADR LHRVAAHYFR DPERADHWQR QALEIHEEIC QQAWSPARGA
     FTTFWGGTKV GPSVLRLAEL GFISPEDARF RGTVRAFEAD AALCASCLKG ADGEVLGEES
     ILKAFATCFT TNTLLWYSEA LRSIGATVES RRLVEALLRT SKHPGMLAEA IDLRTGEQWG
     NTPCTSALLS LLRVAPRLSR TWREV
//