ID   A0A813FCE3_POLGL        Unreviewed;       369 AA.
AC   A0A813FCE3;
DT   29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 1.
DT   05-FEB-2025, entry version 12.
DE   RecName: Full=2-dehydropantoate 2-reductase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PGLA1383_LOCUS26020 {ECO:0000313|EMBL:CAE8608136.1};
OS   Polarella glacialis (Dinoflagellate).
OC   Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Suessiaceae; Polarella.
OX   NCBI_TaxID=89957 {ECO:0000313|EMBL:CAE8608136.1, ECO:0000313|Proteomes:UP000654075};
RN   [1] {ECO:0000313|EMBL:CAE8608136.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Dougan E. K., Rhodes N., Thang M., Chan C.;
RL   Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CAE8608136.1}.
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DR   EMBL; CAJNNV010022473; CAE8608136.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A813FCE3; -.
DR   OMA; HVYGKKF; -.
DR   OrthoDB; 442759at2759; -.
DR   Proteomes; UP000654075; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR013752; KPA_reductase.
DR   InterPro; IPR051402; KPR-Related.
DR   InterPro; IPR013332; KPR_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR21708:SF26; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR   PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000654075}.
FT   DOMAIN          10..173
FT                   /note="Ketopantoate reductase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02558"
FT   DOMAIN          220..342
FT                   /note="Ketopantoate reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08546"
SQ   SEQUENCE   369 AA;  37839 MW;  3268B02A6585F49D CRC64;
     MVTILANATG GVGGWLATRL VASGSAQVQI IARGAHGAAI RDRGLRLRIR QEQISDNISG
     AATAGALVEL APGAVEVYTD VAEAKAKNMQ PADFVILCVK SWQVEAAAAE AVKLLAPGGC
     LVTTQNGVQA PIEAAKAAGH DRVLAGICKV LAFVAEPGLI EMEASPARFH FGEAFAQDGS
     ELRSGSAANG HEGRAERLAA AFAGCAGVTA GVVPEPGAWA AIWEKANLMC CLGPVGALCR
     APMEQLVGIP ETRQLLKDAM AEVAACSAAA GHRDPAVPPA EFAEGLLLAL DKSCKPGTTT
     STTRDVLTGR PSELYELTGG IRHAGRSLGV PTPTHDLIFA ALLPQERRAR GESAYTLMGV
     PGGSPHVQG
//