ID A0A814G2H5_9BILA Unreviewed; 861 AA.
AC A0A814G2H5;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE RecName: Full=NAD(P)(+)--arginine ADP-ribosyltransferase {ECO:0000256|RuleBase:RU361228};
DE EC=2.4.2.31 {ECO:0000256|RuleBase:RU361228};
DE AltName: Full=Mono(ADP-ribosyl)transferase {ECO:0000256|RuleBase:RU361228};
GN ORFNames=BJG266_LOCUS15382 {ECO:0000313|EMBL:CAF0990808.1},
GN QVE165_LOCUS10849 {ECO:0000313|EMBL:CAF0926486.1};
OS Adineta steineri.
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Bdelloidea; Adinetida; Adinetidae; Adineta.
OX NCBI_TaxID=433720 {ECO:0000313|EMBL:CAF0990808.1, ECO:0000313|Proteomes:UP000663877};
RN [1] {ECO:0000313|EMBL:CAF0990808.1}
RP NUCLEOTIDE SEQUENCE.
RA Nowell W R.;
RL Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00048988};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-
CC arginyl-[protein] + nicotinamide + H(+); Xref=Rhea:RHEA:19149,
CC Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:142554; EC=2.4.2.31;
CC Evidence={ECO:0000256|ARBA:ARBA00047597,
CC ECO:0000256|RuleBase:RU361228};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009558, ECO:0000256|RuleBase:RU361228}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAF0990808.1}.
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DR EMBL; CAJNOM010000051; CAF0926486.1; -; Genomic_DNA.
DR EMBL; CAJNOI010000068; CAF0990808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A814G2H5; -.
DR OrthoDB; 10262986at2759; -.
DR Proteomes; UP000663832; Unassembled WGS sequence.
DR Proteomes; UP000663877; Unassembled WGS sequence.
DR GO; GO:0000112; C:nucleotide-excision repair factor 3 complex; IEA:TreeGrafter.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IEA:TreeGrafter.
DR GO; GO:0097550; C:transcription preinitiation complex; IEA:TreeGrafter.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0106274; F:NAD+-protein-arginine ADP-ribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR FunFam; 3.40.50.300:FF:000077; Probable DNA repair helicase RAD25; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.90.176.10; Toxin ADP-ribosyltransferase, Chain A, domain 1; 1.
DR InterPro; IPR000768; ART.
DR InterPro; IPR050615; ATP-dep_DNA_Helicase.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF01129; ART; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51996; TR_MART; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU361228}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW NAD {ECO:0000256|RuleBase:RU361228}; NADP {ECO:0000256|RuleBase:RU361228};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000663832};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361228}.
FT DOMAIN 475..637
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 861 AA; 98930 MW; FC2626AD917720B7 CRC64;
MATSGNVDSQ QYARVSDILK EPQKMLMPIR GYEEMPIVPL EEAVAPLISI LPEIQDYAYV
AKQRCEYVPP NGLTQDESAS IILYSMEWEP HEKYLYFALN TALRAEDRRK LKPWFSYLKL
ILTALEKLPS TRCNVFRGVN LDLTNQYTEG KTFVWWGFSS CTTSVGVLEN EQFLGKTGRR
TLFTIECDSG KDISRHSYYE SEKEVLLLAA RQFIVVSCLR LAPGLHMIQL KETKPPITLL
QPVTNQSVQI KPSPNSYQSN HSTISTATIP KNPITTHQTT TQSQIKQNNN IVLELITTDY
KRAQDFLFAI AEPIHRSEHT QEYELTSNSI HSAMFSGLQT QDMIRDLQQL SKTNISNDLI
NYIKSCTEMY GKVKLVLKNR RYFIESIFPN ILNELLQDSE IKECRAISTE QGLNLESFEV
IQQKIESLKK RCQQLKYPLL EEYDFVHDTM TKNLNIQLAP DANLRPYQEE SLRKMFNNGR
ARSGIIVLPC GAGKSLVGVA AACHMKKNCL VLCNSNVSVE QWKEQFKRWS TADDSIVRSY
TANKKDKLNG SACIFISTYQ MVAPKKGRII ETSKILEKLT NYEWGLILLD EVHTAPAKTF
RKILSIVPAQ IKLGLSATLV REDDKIIDLN YLVGPKLYEA NWMELQNLGF IAKVHCAEVR
CEMTSEFLKE YTTATNHMVK RRLSVCNPNK FRTCQSLIQY HEQRNNKIIV FSDDLFALET
YALKLDKPFI HGRVGDTSFD LPEANVVIQI SSHGRSRRQE AQRLGRISRI KKDIINTNEN
NAFFYTLISE DTNEMKYSSY RQSFLIDQGY TYAMLTHTQI ITNENQLYFS TNEEQRELLE
QIPRTPNNDE ALPITTKKNF K
//
