ID A0A814KTE9_9BILA Unreviewed; 554 AA.
AC A0A814KTE9;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 18-JUN-2025, entry version 15.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=JXQ802_LOCUS27674 {ECO:0000313|EMBL:CAF1264756.1},
GN PYM288_LOCUS17416 {ECO:0000313|EMBL:CAF1056404.1};
OS Rotaria sordida.
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Bdelloidea; Rotaria.
OX NCBI_TaxID=392033 {ECO:0000313|EMBL:CAF1056404.1, ECO:0000313|Proteomes:UP000663854};
RN [1] {ECO:0000313|EMBL:CAF1056404.1}
RP NUCLEOTIDE SEQUENCE.
RA Nowell W R.;
RL Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC {ECO:0000256|ARBA:ARBA00005884}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAF1056404.1}.
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DR EMBL; CAJNOH010000490; CAF1056404.1; -; Genomic_DNA.
DR EMBL; CAJNOL010001012; CAF1264756.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A814KTE9; -.
DR Proteomes; UP000663854; Unassembled WGS sequence.
DR Proteomes; UP000663870; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20343; BRcat_RBR_HHARI-like; 1.
DR CDD; cd20356; Rcat_RBR_HHARI-like; 1.
DR CDD; cd16626; RING-HC_RBR_HHARI; 1.
DR FunFam; 1.20.120.1750:FF:000002; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 3.30.40.10:FF:000019; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045840; Ariadne.
DR InterPro; IPR048962; ARIH1-like_UBL.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF19422; Ariadne; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR Pfam; PF21235; UBA_ARI1; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000663870};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 178..389
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 182..228
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 424..451
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..31
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..70
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 65009 MW; 84EA2C39AEFF4E6E CRC64;
MADDDQFNID DNSEDIEEDE DEEEEGSDDD TGFFPIDEPI VHSSQSNNIT TTTTRHSSEQ
STTKLSSSLS GASNNYLQDN NFEYIVLSQD EIVKYMVECI KEVNEVIKLP TTTVRLLLHH
FRWDKEKLME RFYDPNYQDE LFRQAHIVNP FKKPSQLQTQ LSNSLHRSTR RQISSSPSTQ
TCIICCSTKF LNEMAGLECG HIFCIECWGH YLTTKIMDEG IGQTIPCPAK CDILVDDKTV
LNLINIPTVR RKYQHLITNS FVECNRNMRW CPGTNCTNAI KASYCDVAMV TCTTCRTSFC
FQCGQSWHEP IKCKWLKKWQ KKCHDDSETS NWIAANTKEC PKCHATIEKN GGCNHLICKN
QSCKYEFCWI CLGPWEPHGS SWYNCNRFNE DDAKKARDDQ ERSRAALQRY LHYYKRYHNH
HESLRLESKL LDQVQKRMES MQQQMSWIEV QFLQVACEVL RQCRQTLMYT YPFAFYLKRN
NHSIIFEQNQ ADLELATEEL SGYLERDSNQ TTNLTEMKQK VQDKYRYCST RRKVLLDHVA
EGYECDYWEY NEDV
//
