ID A0A815G112_9BILA Unreviewed; 256 AA.
AC A0A815G112;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 08-OCT-2025, entry version 16.
DE RecName: Full=IGFBP-related protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=JBS370_LOCUS13225 {ECO:0000313|EMBL:CAF3762771.1},
GN JXQ802_LOCUS31141 {ECO:0000313|EMBL:CAF1332528.1}, ZHD862_LOCUS25968
GN {ECO:0000313|EMBL:CAF1262261.1};
OS Rotaria sordida.
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Bdelloidea; Philodinida; Philodinidae; Rotaria.
OX NCBI_TaxID=392033 {ECO:0000313|EMBL:CAF1332528.1, ECO:0000313|Proteomes:UP000663870};
RN [1] {ECO:0000313|EMBL:CAF1332528.1}
RP NUCLEOTIDE SEQUENCE.
RA Nowell W R.;
RL Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAF1332528.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CAJNOT010001906; CAF1262261.1; -; Genomic_DNA.
DR EMBL; CAJNOL010001301; CAF1332528.1; -; Genomic_DNA.
DR EMBL; CAJOBD010001120; CAF3762771.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A815G112; -.
DR Proteomes; UP000663836; Unassembled WGS sequence.
DR Proteomes; UP000663864; Unassembled WGS sequence.
DR Proteomes; UP000663870; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:TreeGrafter.
DR CDD; cd00104; KAZAL_FS; 1.
DR FunFam; 2.60.40.10:FF:000032; palladin isoform X1; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR011390; IGFBP_rP_mac25.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR PANTHER; PTHR14186; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14186:SF19; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000663870};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..256
FT /note="IGFBP-related protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036227481"
FT DOMAIN 22..103
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 80..147
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 149..249
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 256 AA; 27996 MW; 5D49E39974C86649 CRC64;
MATLHLVTLL VLTIFCSIVI AQNKPCESCD SSKCPLTLDK ECLAGLTLDR CGCCQVCAQR
ESELCNHPDV PSSKQYEACG ENLQCKLRMD NRGAPREALC ECNDQVEVCG SDGKTYRNYC
HLMESSKLAK IEQKPVIKVF KRKPCDSAPE ITLPPVSVSN KTGSNVYLTC EAAGVPLPVV
EWVYTAPTGK QIVYPTDDDR VSTLVRGGPN AHVLTSWLQI QSLQRNDQGT YTCIASNTLG
KVEKSCTVSV ETGRDL
//
