ID   A0A815V1K7_9BILA        Unreviewed;       131 AA.
AC   A0A815V1K7;
DT   29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 1.
DT   05-FEB-2025, entry version 8.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 11 {ECO:0000256|ARBA:ARBA00019621, ECO:0000256|RuleBase:RU364147};
DE   AltName: Full=Mediator complex subunit 11 {ECO:0000256|ARBA:ARBA00032011, ECO:0000256|RuleBase:RU364147};
GN   Name=MED11 {ECO:0000256|RuleBase:RU364147};
GN   ORFNames=NZN594_LOCUS44404 {ECO:0000313|EMBL:CAF1524689.1};
OS   Rotaria sp. Silwood1.
OC   Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC   Bdelloidea; Rotaria.
OX   NCBI_TaxID=2762511 {ECO:0000313|EMBL:CAF1524689.1, ECO:0000313|Proteomes:UP000663835};
RN   [1] {ECO:0000313|EMBL:CAF1524689.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Nowell W R.;
RL   Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional pre-initiation complex with RNA polymerase II
CC       and the general transcription factors. {ECO:0000256|RuleBase:RU364147}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000256|RuleBase:RU364147}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU364147}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC       {ECO:0000256|ARBA:ARBA00008186, ECO:0000256|RuleBase:RU364147}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CAF1524689.1}.
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DR   EMBL; CAJNOP010000417; CAF1524689.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A815V1K7; -.
DR   Proteomes; UP000663835; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.287.3490; -; 1.
DR   InterPro; IPR019404; Mediator_Med11.
DR   Pfam; PF10280; Med11; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU364147};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364147};
KW   Reference proteome {ECO:0000313|Proteomes:UP000663835};
KW   Transcription {ECO:0000256|RuleBase:RU364147};
KW   Transcription regulation {ECO:0000256|RuleBase:RU364147}.
SQ   SEQUENCE   131 AA;  15014 MW;  2D2162833249B52E CRC64;
     MTDFTNTTSH TLEQLRQAEN KLTTMLWHAG NIVQQLSSEQ VPREQIESIA RSFSENAQAV
     QLLLHTSVAN LERISSGLPH EDSCYGAWLD FNLASMRTET IRNKLYELKN NSQLQRSRER
     VKELEGQLAQ L
//