ID A0A820K456_9BILA Unreviewed; 967 AA.
AC A0A820K456;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 05-FEB-2025, entry version 13.
DE RecName: Full=Transient receptor ion channel domain-containing protein {ECO:0000259|SMART:SM01420};
GN ORFNames=UJA718_LOCUS14763 {ECO:0000313|EMBL:CAF4335239.1};
OS Rotaria socialis.
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Bdelloidea; Rotaria.
OX NCBI_TaxID=392032 {ECO:0000313|EMBL:CAF4335239.1, ECO:0000313|Proteomes:UP000663873};
RN [1] {ECO:0000313|EMBL:CAF4335239.1}
RP NUCLEOTIDE SEQUENCE.
RA Nowell W R.;
RL Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAF4335239.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CAJOBP010002117; CAF4335239.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A820K456; -.
DR Proteomes; UP000663873; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0015279; F:store-operated calcium channel activity; IEA:TreeGrafter.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:TreeGrafter.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR PANTHER; PTHR10117:SF54; TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000663873};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 728..752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 97..129
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 132..194
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 814..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..831
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 967 AA; 112529 MW; 3D78592484375EBD CRC64;
MCVHRLLIDD EVEADVSNKM GKSALQLAIE NEHFEVVKVL LDKIPYEKFR DALLLAIYLG
HTNIADFIMN HPTYRTFSGG FLDPTHPQAY DDSQFSSDIT PLILAAQYNR LQIVHQLLSK
GERIQKPHKS MCPCVDCADS SAYDSFRQAQ VRLSAYKGLS SEVYIALTYP DPILQAFELN
HEIRTLAKVE HYFREDYEKL SHQLSIFVTR LLDNVRGHEE LEIVLNKTGQ PHEEKYENLA
RFDLAIINQE KAFVSHSNCQ QKLMEKWYEN LSAIKNAHLT KRILFYLAFI VCLPFLLLAY
YFFPQTKIGS LCHQPNLKLK AYIVSYLTFI SLIVASSYFS ISHLQKTKFL SNYNSTIYKF
YIENIYENDQ LRYDLNSLNQ NSQANKNDRL ISCDISLRFM EPNPFQIAIF IWVIGFVWQE
IKQLFGAGVR VYLKSHSNYV DCLMNILYIL YFICLYSSMV LTRTSMNMFH SSDYWRNIVR
YDNMRESEKV EYLGKTYHIL YWLNADRYYW SSNDLQNLAE AFFAMGNVAS ICRICFLLPI
IGFVGPLQVM LERMIIDISK WIVIILIFFV AFACSLFLIF SPFATALKQH DILHSTSNTA
ASQIVSLMRY ETLSMSTSAR CLPYYKLINQ SFPNVTALDA PDVANLDENN SCKQSKQYDK
IENVGPHPAI HYFGEKFGST ILTTFFTLFG DMAEDDIPDR GYELISLTCN KPDPKSYAPG
FDIFSSNLGF IIFGLFTFIC VTVLINTLIA MMGKTIDIID NRADVEWKFA RSRLYMEYVR
DGNSLPVPMN ICPTPKSFIH LFKRIKNLIL SKNSSDDDDE RANETGDDRL DGLNIRRRNH
DDDNDNDINI KGTQHDRFKH EKIFDRQRSY AIHEKLTYKI VIERIIRRFL IHYKNKHTGA
NENNDGLEFK EFKNDVSSLR FELLNEVDML DDMRLLIGEP MNKFNDILEM NFDMDKIKEY
LHDQKLI
//
