ID A0A830GPH5_9EURY Unreviewed; 348 AA.
AC A0A830GPH5;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=DNA repair and recombination protein RadA {ECO:0000256|ARBA:ARBA00018144, ECO:0000256|HAMAP-Rule:MF_00348};
GN Name=radA {ECO:0000256|HAMAP-Rule:MF_00348};
GN ORFNames=GCM10009030_31410 {ECO:0000313|EMBL:GGN99631.1};
OS Haloarcula pellucida.
OC Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
OC Halobacteria; Halobacteriales; Haloarculaceae; Haloarcula.
OX NCBI_TaxID=1427151 {ECO:0000313|EMBL:GGN99631.1, ECO:0000313|Proteomes:UP000605784};
RN [1] {ECO:0000313|EMBL:GGN99631.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 17820 {ECO:0000313|EMBL:GGN99631.1};
RX PubMed=25193709;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Walter F., Albersmeier A., Kalinowski J., Ruckert C.;
RT "Complete genome sequence of Corynebacterium casei LMG S-19264T (=DSM
RT 44701T), isolated from a smear-ripened cheese.";
RL Int. J. Syst. Evol. Microbiol. 189:76-77(2014).
RN [2] {ECO:0000313|EMBL:GGN99631.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 17820 {ECO:0000313|EMBL:GGN99631.1};
RA Sun Q., Ohkuma M.;
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in DNA repair and in homologous recombination. Binds
CC and assemble on single-stranded DNA to form a nucleoprotein filament.
CC Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand
CC exchange between homologous DNA molecules. {ECO:0000256|HAMAP-
CC Rule:MF_00348, ECO:0000256|PIRNR:PIRNR005856}.
CC -!- SIMILARITY: Belongs to the eukaryotic RecA-like protein family.
CC {ECO:0000256|ARBA:ARBA00008050, ECO:0000256|HAMAP-Rule:MF_00348,
CC ECO:0000256|PIRNR:PIRNR005856}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GGN99631.1}.
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DR EMBL; BMOU01000005; GGN99631.1; -; Genomic_DNA.
DR RefSeq; WP_189000103.1; NZ_BMOU01000005.1.
DR AlphaFoldDB; A0A830GPH5; -.
DR Proteomes; UP000605784; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00348; RadA_arch; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011938; DNA_recomb/repair_RadA.
DR InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013632; Rad51_C.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR NCBIfam; NF003301; PRK04301.1; 1.
DR NCBIfam; TIGR02236; recomb_radA; 1.
DR PANTHER; PTHR22942:SF30; MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG; 1.
DR PANTHER; PTHR22942; RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF08423; Rad51; 2.
DR PIRSF; PIRSF005856; Rad51; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47794; Rad51 N-terminal domain-like; 1.
DR PROSITE; PS50162; RECA_2; 1.
DR PROSITE; PS50163; RECA_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00348};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00348};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172, ECO:0000256|HAMAP-
KW Rule:MF_00348};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00348};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00348}; Reference proteome {ECO:0000313|Proteomes:UP000605784}.
FT DOMAIN 79..283
FT /note="RecA family profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50162"
FT DOMAIN 288..348
FT /note="RecA family profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50163"
FT BINDING 108..115
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00348"
SQ SEQUENCE 348 AA; 37470 MW; 71BED36CC400B7CB CRC64;
MSASEDLEDL PGVGPATAEK LKENGFDSYQ GIAVASPGEL SNTADIGESS AADIINAARD
AADIGGFETG ATVLERREQI GKLTWGVDEV DDLLGGGVET QSITEVYGEF GAGKSQVTHQ
LAVNVQLPAE HGGLEGSAIF IDSEDTFRPE RIEQMVEGQD DEVLEDTMEL HGVAEEGEAD
ATDEAMFDAL VESVLDKIHV AKAFNSNHQI LLAEKAQEIA SETQEEEFPV RLLAVDSLTA
HFRAEYVGRG ELAERQQKLN KHLHDLMRVG DLNNTAVVVT NQVASNPDSF FGDPTQPIGG
NILGHTSTFR IYLRKSKGDK RIVKLVDAPN LPDGEGVMRV EEGGLMNE
//
