ID A0A834HVS8_RHYFE Unreviewed; 503 AA.
AC A0A834HVS8;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 18-JUN-2025, entry version 15.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=GWI33_019608 {ECO:0000313|EMBL:KAF7267111.1};
OS Rhynchophorus ferrugineus (Red palm weevil) (Curculio ferrugineus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Dryophthorinae; Rhynchophorus.
OX NCBI_TaxID=354439 {ECO:0000313|EMBL:KAF7267111.1, ECO:0000313|Proteomes:UP000625711};
RN [1] {ECO:0000313|EMBL:KAF7267111.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AA-2017 {ECO:0000313|EMBL:KAF7267111.1};
RC TISSUE=Whole larva {ECO:0000313|EMBL:KAF7267111.1};
RA Dias G.B., Bergman C.M., Manee M.;
RT "Genome sequencing and assembly of the red palm weevil Rhynchophorus
RT ferrugineus.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC {ECO:0000256|ARBA:ARBA00005884}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF7267111.1}.
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DR EMBL; JAACXV010014465; KAF7267111.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A834HVS8; -.
DR OrthoDB; 10009520at2759; -.
DR Proteomes; UP000625711; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20343; BRcat_RBR_HHARI-like; 1.
DR CDD; cd20356; Rcat_RBR_HHARI-like; 1.
DR CDD; cd16626; RING-HC_RBR_HHARI; 1.
DR FunFam; 1.20.120.1750:FF:000002; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 3.30.40.10:FF:000019; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045840; Ariadne.
DR InterPro; IPR048962; ARIH1-like_UBL.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF19422; Ariadne; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR Pfam; PF21235; UBA_ARI1; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000625711};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 129..340
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 133..181
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 503 AA; 59073 MW; 4848F954934E35D8 CRC64;
MDSEEETYDD VDSGNESSGD DVDFAMEVEV TGHREIQNDC EDYPYEVLST EQIVQHMVDS
IKDVNSVVEI PATTTRILLN HFRWDKEKLM ERFYDGDQDQ LFNEARVINP FKKLNITSRS
KPLKKAANGM EECEICFMLL PSSHMTGLEC GHRFCVHCWC EYLTTKIMEE GVGQTIACAA
HGCDILVDDA SVMRLVRDSK VRLKYQHLIT NSFVECNRLL RWCPSPDCSN AIKVQYVEPH
RVTCKCNHTF CFSCGENWHD PVKCHLLKKW IKKCDDDSET SNWIAANTKE CPKCNVTIEK
DGGCNHMVCK NQNCKADFCW VCLGPWEPHG SSWYNCNRYD EDEAKAARDA QERSRSALQR
YLFYCNRYMN HMASLKFEHK LYASVKEKME EMQQHNMSWI EVQFLKRAVD ILCQCRQTLM
YTYVFAYYLQ KNNQSVIFED NQRDLESATE TLSEYLERDI TSENLADIKQ KVQDKYRYCD
SRRKVLLEHV HEGYEKEWWD YNE
//
