ID A0A835NZB8_9PASS Unreviewed; 540 AA.
AC A0A835NZB8;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 18-JUN-2025, entry version 15.
DE RecName: Full=E3 ubiquitin-protein ligase ARIH2 {ECO:0000256|ARBA:ARBA00070157};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
DE AltName: Full=Triad1 protein {ECO:0000256|ARBA:ARBA00080593};
DE Flags: Fragment;
GN ORFNames=IHE44_0003577 {ECO:0000313|EMBL:KAI1234522.1}, IHE44_003196
GN {ECO:0000313|EMBL:KAG0127247.1};
OS Lamprotornis superbus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sturnidae; Lamprotornis.
OX NCBI_TaxID=245042 {ECO:0000313|EMBL:KAG0127247.1};
RN [1] {ECO:0000313|EMBL:KAG0127247.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SS15 {ECO:0000313|EMBL:KAG0127247.1};
RC TISSUE=Liver {ECO:0000313|EMBL:KAG0127247.1};
RA Rubenstein D.R.;
RT "Feather gene expression reveals the developmental basis of iridescence in
RT African starlings.";
RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAI1234522.1, ECO:0000313|Proteomes:UP000618051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SS15 {ECO:0000313|EMBL:KAI1234522.1};
RX PubMed=33885791;
RA Rubenstein D.R., Corvelo A., MacManes M.D., Maia R., Narzisi G.,
RA Rousaki A., Vandenabeele P., Shawkey M.D., Solomon J.;
RT "Feather Gene Expression Elucidates the Developmental Basis of Plumage
RT Iridescence in African Starlings.";
RL J. Hered. 112:417-429(2021).
RN [3] {ECO:0000313|EMBL:KAI1234522.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SS15 {ECO:0000313|EMBL:KAI1234522.1};
RC TISSUE=Liver {ECO:0000313|EMBL:KAI1234522.1};
RA Rubenstein D.R.;
RL Submitted (JAN-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC {ECO:0000256|ARBA:ARBA00005884}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG0127247.1}.
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DR EMBL; JADDUC010000016; KAG0127247.1; -; Genomic_DNA.
DR EMBL; JADDUC020000015; KAI1234522.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A835NZB8; -.
DR OrthoDB; 10009520at2759; -.
DR Proteomes; UP000618051; Chromosome 12.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20344; BRcat_RBR_TRIAD1; 1.
DR CDD; cd20360; Rcat_RBR_TRIAD1; 1.
DR CDD; cd16773; RING-HC_RBR_TRIAD1; 1.
DR FunFam; 1.20.120.1750:FF:000004; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 2.20.25.20:FF:000005; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 3.30.40.10:FF:000098; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.20.25.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045840; Ariadne.
DR InterPro; IPR047555; BRcat_RBR_TRIAD1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047556; Rcat_RBR_TRIAD1.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF19422; Ariadne; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM00647; IBR; 2.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000618051};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 182..391
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 347..387
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..44
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..84
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KAG0127247.1"
SQ SEQUENCE 540 AA; 62273 MW; D62B2CF7D98836E6 CRC64;
GSAVPPRPSA VARPGPAPPG GGDAPGPAVP ARRRSSGRRS RRPLARPGIK MSVDMNSQGS
DSNEEDYDPN CEEEEEDEDP GDIEDYYDGV ANDVEQQGAD AFDPEEYQFT CLTYKESEST
LNEHMASLAA TLKVSHAVAK LVLVSFHWQI SEILERHKSN AAQLLVEARV QPTSSKHAMV
HSSHHCAVCM QFVRKENLLS LACQHQFCRS CWEQHCTVLV KDGVGVGVSC MAQDCLLRTP
EDFVFPLLPS EELKDKYRRY LFRDYVESHY QLQLCPGADC PMVIQVQEPK ARRVQCNRCN
EVFCFKCRQM YHAPTDCATI RKWLTKCADD SETANYISAH TKDCPKCNIC IEKNGGCNHM
QCSKCKHDFC WMCLGDWKTH GSEYYECSRY KENPDIVNQS QQAQAREALK KYLFYFERWE
NHNKSLQLEA QTYQRIQEKI QERVMNNLGT WIDWQYLQNA AKLLAKCRYT LQYTYPYAYY
MESGPRKKLF EYQQAQLEAE IENLSWKVER ADSYDRGDLE NQMHIAEQRR RTLLKDFHDT
//
