ID A0A835SVY6_CHLIN Unreviewed; 2317 AA.
AC A0A835SVY6;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=Alpha-2-macroglobulin domain-containing protein {ECO:0000259|SMART:SM01360};
GN ORFNames=HXX76_007940 {ECO:0000313|EMBL:KAG2434214.1};
OS Chlamydomonas incerta.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=51695 {ECO:0000313|EMBL:KAG2434214.1, ECO:0000313|Proteomes:UP000650467};
RN [1] {ECO:0000313|EMBL:KAG2434214.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SAG 7.73 {ECO:0000313|EMBL:KAG2434214.1};
RA Craig R.J., Hasan A.R., Ness R.W., Keightley P.D.;
RT "Comparative genomics of Chlamydomonas.";
RL bioRxiv 0:0-0(2020).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG2434214.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAEHOC010000017; KAG2434214.1; -; Genomic_DNA.
DR OrthoDB; 543368at2759; -.
DR Proteomes; UP000650467; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR PANTHER; PTHR13062:SF12; ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13062; COLLAGENASE; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF17973; bMG10; 1.
DR SMART; SM01360; A2M; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000650467};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2317
FT /note="Alpha-2-macroglobulin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5032949298"
FT DOMAIN 1495..1586
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT REGION 1443..1480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1462..1480
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2317 AA; 238722 MW; 8BF4B16BCCBB41EB CRC64;
MPGLLLVLAT FALVGIQLAA ARTVKPKYFL QKALPLNLVV TTPVDLASSD SSSVSLYGRQ
ALTAVFSRPV IALGSDFGIP ASEQKLPFRL NCPVPGKARW VTTTIARFDA DVDWPTDLDC
ELTWTAGLTS YDGAPLQLGD TPASRKLSSS SLTLSVGDVL SDRAEQLTDG RWAPSLSLPD
DSYREVPPDG RIVVQFSGQV HLATLQSYLK VAEGAQGTGA EAAFSLAPCQ SPAPWIYPYT
STGASSQGAA TPLSLDVNAT CAEVSPRNLK PDTVYAVRLP VGSRYFGLSG PLRAEAVAPF
RSLRPFRFYF QQNTWQSLWT GTKYRRLDLG LLHGLGSAVT PAALAGRISL CARGPGGGCS
PVPFTLSLVD KGLARLSVDG LQPGTQHTIS VTGDASVTDG YDQALQSSSL SFYTAYVDYS
FVGPTLSNMA LLEPAAVDSL ASWPFVSRGP PPLNPDQLWY QPAFANRIDA WEVDIAVERN
RIMLLKSVVQ SSYSQMNLQA IFGAPIASVS VPIELRTPGS GADWQQLALS LAGAKVRVVS
FCCNNQGGLS DAKLLVRSGL SLNVVQLGDT FRAWLLDSNE GASGAAAAVA GATVYIHVLP
NNGRSTVTYT NPDAVMLGSC VTGADGVCTI TSNSASDWSQ VAAFALTTDG RAAVLPSAGY
ISPDSPPANY VASLVADRRV IVPGDSLKIT GFVQQVSATG LKLPAESWVV VEVSPNWQAS
ASGAAGGTTT GGGGVVSPGR GLMVGAVGAA VATDMASAVG SVSTEAALPV ATIAAELPVP
VAGRTGRALR GSTASSAGVS AAAVSVGVST PVVTGARPIV GGGVSTGTTG NALTGVPTRY
FAKIDGASGV LHVEVPIPAD ARLQPYTIQL RLPKPGTAPA SGARPDDATA AGWSDVAGSL
AFTVADPRPP TAELEVDVPP WALPTAAIAL KLTAVSYVGA PVDNSPITVT WSHSKASGVI
KLTTGLDGVA STTLDLGALP EANRTTAYDT LNIAAEWVGP TRELIQKSAT VTLADGPARL
QLQTSLDTDV PGVAFAVGAE LTSNVDGSAI AGVAVTATLK PDTSAGPAAC ADTPSCATTS
GAGLDAGCQL ALPCVGRFVW QACAATASGP VCANQTLGRN STEWATDPLD SFPAPNFLTT
KTSYKIGESA TIRFQNPWAG ARLLLTWGNN VASRYEVVAS LPTGLASHTF GPLGNECLGG
CAVSLVLDVP RLPASALPLP PPEQLRVSKL YDPRAPATYT QQLSLPVLPE NELAVAVAVA
AAPGVAAGSI TDADGKQLLS IEPGSEATVT VTVSGVGAGA SVTVYGVDKA FLDLLPYPLP
APQQEVVLRL AASVSAYGAA AYRLAPGAVQ AVFAKLMSRL TGLDPWLPPD TTVRPGTTSD
YYYSTSVASA AAAVDMEDAA YLALYTTPLT YLASSYSGRF GGCGIYCMDA SAGIGKGNAI
TAPSARPGPG AVTNDQSKES TSDSASGAGA GSGASSAAKT DSGVTVRQEA DFVVTPLFTT
AVTDVSGVAR ATFTAPPNLG TFVLRAFAAS GAAAKYGSGE AKLAVRRALS LTPSVPRFVR
VGDKFEAGVV VTVGSAPASV TVNLILQNAA DSPLTLNGVS SKTVTFAAGG GLQQEVRFDF
TAVAIASATL EFDAVDSAAG GGSDSLSLEL PVYGQQGDVW VATSFALKAL PASDSDVVQW
QEGLALPNAV PGSGGLALTA GVGYWPSIAA TYDNLAQREE DYSGYAYAQP SMLWAVQPPL
LQRYGQPASA AGPEALLHTA YTNLGRLTLS NVGLVYSDPS RWYSWVPTRT DVYLNCWALF
LAAEHAAAGK ALSGDLAAAY AADWAGLAGN LLPLWRAAVE RQVIQDARDA RMYSNNKAAY
EDWYTLAWVR LAMGPSWNPP DWLESPIRND LSLSTLLAAV SAKKAGRETR VLLSLYLQAL
GSAAPSSPLV ANTVAEVTSA LRTQGRTAYV ASGPGAASAS PLDEQALALL LLLRSGATNQ
LVPKLAAYVA NPSQAGGSVP GWFTMYPSEA AQGLAGVALA AYDEARGSTK PDVELFADVN
GLTVLEGTFR TGANAPVSNT TAWEDLPPPP AGSPSELNFE VTGSGEVSVA ASLHFIPSAL
LSFPSYRGLY VEAALQQVDP RTGSATGGRL ASVPLGSVVA LTVQLTTPDD LGAVTLSVMM
PGGLEPLDPN LVSGADSACT DSWVDNNSWG YFYRWYFWFP ICPAQETRPS VVTFNYLSLR
AGTSSVVIKA VAATAGTFVV PPIRAWVDEQ PELMGSTAGA KITVCADCAG PTYGALPPPP
KPCPADCSGN GVCNLKTGKC VCNAFWTRAD CSRMVPA
//
