ID A0A835TT41_9PASS Unreviewed; 563 AA.
AC A0A835TT41;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 08-OCT-2025, entry version 15.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|EMBL:KAG0115639.1};
DE Flags: Fragment;
GN ORFNames=IHE44_0013551 {ECO:0000313|EMBL:KAI1237477.1}, IHE44_005653
GN {ECO:0000313|EMBL:KAG0115639.1};
OS Lamprotornis superbus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sturnidae; Lamprotornis.
OX NCBI_TaxID=245042 {ECO:0000313|EMBL:KAG0115639.1};
RN [1] {ECO:0000313|EMBL:KAG0115639.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SS15 {ECO:0000313|EMBL:KAG0115639.1};
RC TISSUE=Liver {ECO:0000313|EMBL:KAG0115639.1};
RA Rubenstein D.R.;
RT "Feather gene expression reveals the developmental basis of iridescence in
RT African starlings.";
RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAI1237477.1, ECO:0000313|Proteomes:UP000618051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SS15 {ECO:0000313|EMBL:KAI1237477.1};
RX PubMed=33885791;
RA Rubenstein D.R., Corvelo A., MacManes M.D., Maia R., Narzisi G.,
RA Rousaki A., Vandenabeele P., Shawkey M.D., Solomon J.;
RT "Feather Gene Expression Elucidates the Developmental Basis of Plumage
RT Iridescence in African Starlings.";
RL J. Hered. 112:417-429(2021).
RN [3] {ECO:0000313|EMBL:KAI1237477.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SS15 {ECO:0000313|EMBL:KAI1237477.1};
RC TISSUE=Liver {ECO:0000313|EMBL:KAI1237477.1};
RA Rubenstein D.R.;
RL Submitted (JAN-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG0115639.1}.
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DR EMBL; JADDUC010000211; KAG0115639.1; -; Genomic_DNA.
DR EMBL; JADDUC020000007; KAI1237477.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A835TT41; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000618051; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000618051};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 404..499
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 494..543
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 122..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..323
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KAG0115639.1"
FT NON_TER 563
FT /evidence="ECO:0000313|EMBL:KAG0115639.1"
SQ SEQUENCE 563 AA; 64385 MW; 4A98E03CBF371CAA CRC64;
RENWGRFFRG VSGSRGHLSE GLQALRLCRI RSDTAPNAKF YFEIRLGTRA GLINRCEWLR
AGREPRIAAL LGFWVEHGVL VMDHKAFTDL VLERLLRKGS SLMKMTVGLE ARIQQLRTKA
VTMAENKDSS AKNADVRPKS SRSRSADRKD GYVWSGKKLS WSKKSEHCPD AETASTAGRP
GNNLRSQERK YSCSSIELDL DRSCGHRFLG RSLKQKLQDA VGQCFPIKNC SSRHASGLPS
KRKIHISELM LDKCPFPPRS ELAFRWHLIK RHTAPISPKA EEWIIADLSQ HEEREDQLQD
EEIANGGMDS PSPSCDFPDS SSSRGDPRPE LVTGKVARSS RDESDMDSDD EVITLCTSSR
KRNKPKWETD DELLRMETPP KYHTQIDYVH CLVPDLLQIN NNPCYWGVMD KYAAEALLEG
KPEGTFLLRD SAQEDYLFSV SFRRYSRSLH ARIEQWNHNF SFDAHDPCVF HSPDITGLLE
HYKDPSSCMF FEPLLSTPLN RTFPFSLQHI CRTVICNCTT YDGIDALPIP PSVKLYLKEY
HYKSKVRVLR IDTLVDLQYK EEI
//
