ID   A0A840P9D2_9ACTN        Unreviewed;       295 AA.
AC   A0A840P9D2;
DT   29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 1.
DT   02-APR-2025, entry version 14.
DE   SubName: Full=4-hydroxy-tetrahydrodipicolinate synthase {ECO:0000313|EMBL:MBB5135246.1};
DE            EC=4.3.3.7 {ECO:0000313|EMBL:MBB5135246.1};
GN   ORFNames=HNP84_004982 {ECO:0000313|EMBL:MBB5135246.1};
OS   Thermocatellispora tengchongensis.
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Thermocatellispora.
OX   NCBI_TaxID=1073253 {ECO:0000313|EMBL:MBB5135246.1, ECO:0000313|Proteomes:UP000578449};
RN   [1] {ECO:0000313|EMBL:MBB5135246.1, ECO:0000313|Proteomes:UP000578449}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45615 {ECO:0000313|EMBL:MBB5135246.1,
RC   ECO:0000313|Proteomes:UP000578449};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT   most valuable type-strain genomes for metagenomic binning, comparative
RT   biology and taxonomic classification.";
RL   Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000256|ARBA:ARBA00007592,
CC       ECO:0000256|PIRNR:PIRNR001365}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:MBB5135246.1}.
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DR   EMBL; JACHGN010000010; MBB5135246.1; -; Genomic_DNA.
DR   RefSeq; WP_185052185.1; NZ_BAABIX010000015.1.
DR   AlphaFoldDB; A0A840P9D2; -.
DR   Proteomes; UP000578449; Unassembled WGS sequence.
DR   GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IEA:TreeGrafter.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128:SF66; 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW   Reference proteome {ECO:0000313|Proteomes:UP000578449}.
FT   ACT_SITE        138
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        164
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         49
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   295 AA;  31936 MW;  D161339145B41D6E CRC64;
     MRSLDLHGMI STVVTPFDEH DRVDLDLLRG EVKYLLDAGV TAICACGSTG EGQTLSLEES
     TDICRVVVEE VAGRVPVIAG VIQNSTAQVI RYSLALKETG VDALQITPVH YVFSPSADET
     VAYFREIGEA VDLPIVLYNV VPWALVPVDV IERLAEVPQL VAVKQSGGDM HLLVDLLARV
     RDRFTILAAL DDLHYPAFML GAHGALAAIP TVTPRLSVEL WNAVQAGDHD LARELHERIL
     TVWRAIDGPN LPATLKAALR LQGRDGGLPR RPFSPASPAE RERIAAALRA ANLIA
//