ID A0A844FI47_9FIRM Unreviewed; 642 AA.
AC A0A844FI47;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:MSS43608.1};
GN ORFNames=FYJ27_07695 {ECO:0000313|EMBL:MSS43608.1}, L0P62_10395
GN {ECO:0000313|EMBL:MCG4565859.1};
OS Anaerosalibacter bizertensis.
OC Bacteria; Bacillati; Bacillota; Tissierellia; Tissierellales;
OC Sporanaerobacteraceae; Anaerosalibacter.
OX NCBI_TaxID=932217 {ECO:0000313|EMBL:MSS43608.1, ECO:0000313|Proteomes:UP000462760};
RN [1] {ECO:0000313|EMBL:MSS43608.1, ECO:0000313|Proteomes:UP000462760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Med78-601-WT-4W-RMD-3 {ECO:0000313|EMBL:MSS43608.1,
RC ECO:0000313|Proteomes:UP000462760};
RA Wylensek D., Hitch T.C.A., Clavel T.;
RT "In-depth cultivation of the pig gut microbiome towards novel bacterial
RT diversity and tailored functional studies.";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MCG4565859.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MSK.14.39 {ECO:0000313|EMBL:MCG4565859.1};
RA Lin H., Kohout C., Waligurski E., Pamer E.G.;
RT "Collection of gut derived symbiotic bacterial strains cultured from
RT healthy donors.";
RL Submitted (JAN-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MSS43608.1}.
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DR EMBL; JAKNID010000059; MCG4565859.1; -; Genomic_DNA.
DR EMBL; VULR01000009; MSS43608.1; -; Genomic_DNA.
DR RefSeq; WP_154484288.1; NZ_JAJBNW010000075.1.
DR AlphaFoldDB; A0A844FI47; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000462760; Unassembled WGS sequence.
DR Proteomes; UP001108123; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:MSS43608.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP001108123}.
FT DOMAIN 1..176
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 642 AA; 73756 MW; 7ED50DEB1D996D67 CRC64;
MKHFIVGTAG HIDHGKTTLI KALTGRETDR LKEEQKRGIS IELGFTYFDL PSGKRAGIID
VPGHEKFVKN MLAGVIGIDI VILVVAADEG VMPQTKEHLD ILQLLGIKKG FIVLTKIDLV
DEEWMELVME DIKEHVKNTF LENTPIIPVS SIKNIGLDEV RDNIDNLTEE IEERNVKDMP
RLPIDRVFTI SGFGTIVTGT LISGTFKVGD EVEIFPGNKR GRIRSLQVHD EAADIVEAGQ
RVAMNIAGLK KSSIDRGNVV APIDSMKDTM MLDVKVKLLE DIPKIIENRS RVRLYIGTQE
ILCRIVLLDK EELSPGESAY AQLRLEESTV AKRGDKFILR FYSPMFTIGG GEVLEANPEK
KKRFDKQAIE ELEIKDKGET EDVIGKVIKD RSKEFPTVKD ISIYTAMSEE DVSREIENLK
FKNKVITFSL LKDIHVIHIE YFNYLQGKIE EELKKYHIDR PLKQGIGKEE IRSKYFKDIK
PRVADEFINL LIKKGIVKQK NEYIFLEGFE IKYNEEQNKI KEEIKKIFIR EEFLLPKYED
IVKEIKFDDD EIRQVFESLL DSGEVLKLKE DIYILKDIYE RAIAILNEYL DKNGSITVSQ
YRDLLNTNRK SSIALLEYFD EIKITKRVGD KRIFTGKIEE NR
//
