ID A0A850ZGN6_9PASS Unreviewed; 220 AA.
AC A0A850ZGN6;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 05-FEB-2025, entry version 11.
DE RecName: Full=Calcyclin-binding protein {ECO:0000256|ARBA:ARBA00015702};
DE Flags: Fragment;
GN Name=Cacybp {ECO:0000313|EMBL:NWI04244.1};
GN ORFNames=TICMUR_R10567 {ECO:0000313|EMBL:NWI04244.1};
OS Tichodroma muraria.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sittidae; Tichodroma.
OX NCBI_TaxID=237442 {ECO:0000313|EMBL:NWI04244.1, ECO:0000313|Proteomes:UP000629438};
RN [1] {ECO:0000313|EMBL:NWI04244.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B10K-DU-012-47 {ECO:0000313|EMBL:NWI04244.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in calcium-dependent ubiquitination and
CC subsequent proteasomal degradation of target proteins. Probably serves
CC as a molecular bridge in ubiquitin E3 complexes. Participates in the
CC ubiquitin-mediated degradation of beta-catenin (CTNNB1).
CC {ECO:0000256|ARBA:ARBA00025145}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWI04244.1}.
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DR EMBL; WAAG01067062; NWI04244.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A850ZGN6; -.
DR OrthoDB; 164025at2759; -.
DR Proteomes; UP000629438; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0044548; F:S100 protein binding; IEA:InterPro.
DR GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0007507; P:heart development; IEA:TreeGrafter.
DR CDD; cd06468; p23_CacyBP; 1.
DR FunFam; 2.60.40.790:FF:000006; calcyclin-binding protein-like; 1.
DR FunFam; 4.10.860.10:FF:000006; calcyclin-binding protein-like; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR037201; CacyBP_N.
DR InterPro; IPR052289; Calcyclin-binding_UBL-bridge.
DR InterPro; IPR037893; CS_CacyBP.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR007699; SGS_dom.
DR InterPro; IPR015120; Siah-Interact_N.
DR PANTHER; PTHR13164:SF3; CALCYCLIN-BINDING PROTEIN; 1.
DR PANTHER; PTHR13164; CALICYLIN BINDING PROTEIN; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF05002; SGS; 1.
DR Pfam; PF09032; Siah-Interact_N; 1.
DR SUPFAM; SSF140106; Calcyclin-binding protein-like; 1.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR PROSITE; PS51203; CS; 1.
DR PROSITE; PS51048; SGS; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000629438};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 65..158
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT DOMAIN 143..220
FT /note="SGS"
FT /evidence="ECO:0000259|PROSITE:PS51048"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWI04244.1"
FT NON_TER 220
FT /evidence="ECO:0000313|EMBL:NWI04244.1"
SQ SEQUENCE 220 AA; 25496 MW; 34B3B02A058D2857 CRC64;
PLFLNQLQKD LEEVKELLTN ATRKRVRDVL VAEKQKLELE IKNQPPPKPK DVAEEEKSSL
GGYTVKINNY GWDQSDKFVK IYISLNGVQK LPAENVQVNF TERSFDLLVK NLNGKNYTMT
FNNLLKPISV EGSSRKIKTD MVLVMCKKKR EEKWDCLTQV EKESKEKEKA AYDTTDPSEG
LMNILKKMYA EGDDEMKRTI NKAWVESREK QYKGDIPMDI
//
