ID A0A851DUT8_TODME Unreviewed; 643 AA.
AC A0A851DUT8;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE RecName: Full=Platelet-derived growth factor receptor-like protein {ECO:0000256|ARBA:ARBA00019671};
DE Flags: Fragment;
GN Name=Pdgfrb {ECO:0000313|EMBL:NWI71993.1};
GN ORFNames=TODMEX_R05677 {ECO:0000313|EMBL:NWI71993.1};
OS Todus mexicanus (Puerto Rican tody).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Coraciimorphae;
OC Coraciiformes; Todidae; Todus.
OX NCBI_TaxID=135184 {ECO:0000313|EMBL:NWI71993.1, ECO:0000313|Proteomes:UP000660247};
RN [1] {ECO:0000313|EMBL:NWI71993.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B10K-DU-002-69 {ECO:0000313|EMBL:NWI71993.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NWI71993.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] +
CC ADP + H(+); Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:20101, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:61978, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00051243};
CC -!- SUBUNIT: Forms a complex composed of PDGFRL, TNK2 and GRB2.
CC {ECO:0000256|ARBA:ARBA00011360}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWI71993.1}.
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DR EMBL; WEIS01322641; NWI71993.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A851DUT8; -.
DR OrthoDB; 9936425at2759; -.
DR Proteomes; UP000660247; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00096; Ig; 1.
DR FunFam; 2.60.40.10:FF:000223; Platelet-derived growth factor receptor beta; 1.
DR FunFam; 2.60.40.10:FF:000572; Platelet-derived growth factor receptor beta; 1.
DR FunFam; 2.60.40.10:FF:000715; Platelet-derived growth factor receptor beta; 1.
DR FunFam; 2.60.40.10:FF:000982; Platelet-derived growth factor receptor beta; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR042495; PDGFRL.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR15360; PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE; 1.
DR PANTHER; PTHR15360:SF4; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF25305; Ig_PDGFR_d4; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 1.
DR PRINTS; PR01832; VEGFRECEPTOR.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000615-2, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000615-2, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000660247};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 522..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..105
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 201..296
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 312..397
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 405..514
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 590..643
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 569
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
FT BINDING 597..604
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-2"
FT BINDING 624
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWI71993.1"
FT NON_TER 643
FT /evidence="ECO:0000313|EMBL:NWI71993.1"
SQ SEQUENCE 643 AA; 72291 MW; 0F7906F5822E3F7B CRC64;
PICFHLPVLP GLLEVTSGGS GLHIEPRDAE LVLDLHSTFS LLCYGAGELI WEQEGQPLAA
SLEHRDGVFI SNLTLSNVTG RHTGEYTCTY SPEQAPEPVE RKALYIYVPD PSLVFLPTVN
FEEIFIFIMG YTEAVIPCRV TNPQMQVTLY EKKVENPIPA AYDPRQGFKG FFEDKTYFCR
TIVDDQEVDS DTFYVYRIQV SSVNVSISAV QTIVRQGENV TLMCTVSGNE LVNFNWDYPR
KQAGKAVEPV TDFLPGSSHE IRSILIIQNA ELEDSGTYVC NVSEGYHEKA DRKDITVRVI
ERGFVRFHTH LPSSVYAEVH KSHTIQVEVE AYPQPSIVWL KNNQTLTMES SSEFTITSRN
LSETRYQTAL VLVRVKQEEG GLYTIRASNE DDEQELSFHL QINVPAKVVD LKENSSASSG
EQTVTCSAEG MPQPEISWFA CSDIKWCSTK GQPTRLLGNE SAEIGLQTNA MYHEELQVYR
VNSTLRLHRM DEPRLLRCTV QNFLGANSQD ITLVPHTLPF KVVIISVILA LLVLIVISLI
ILIVLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPMQLPYD SSWEVPRDKL VLGRTLGSGA
FGRVVEATAH GLSHSQSTMK VAVKMLKSTA RSSEKQALMS ELK
//
