ID A0A851E974_9CORV Unreviewed; 292 AA.
AC A0A851E974;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 18-JUN-2025, entry version 14.
DE SubName: Full=KAZD1 protein {ECO:0000313|EMBL:NWI79351.1};
DE Flags: Fragment;
GN Name=Kazald1_1 {ECO:0000313|EMBL:NWI79351.1};
GN ORFNames=DRYGAM_R11066 {ECO:0000313|EMBL:NWI79351.1};
OS Dryoscopus gambensis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Corvoidea; Malaconotidae; Dryoscopus.
OX NCBI_TaxID=85069 {ECO:0000313|EMBL:NWI79351.1, ECO:0000313|Proteomes:UP000604080};
RN [1] {ECO:0000313|EMBL:NWI79351.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B10K-DU-002-56 {ECO:0000313|EMBL:NWI79351.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NWI79351.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWI79351.1}.
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DR EMBL; WEIT01024990; NWI79351.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A851E974; -.
DR Proteomes; UP000604080; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:TreeGrafter.
DR CDD; cd00104; KAZAL_FS; 1.
DR FunFam; 2.60.40.10:FF:000032; palladin isoform X1; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR011390; IGFBP_rP_mac25.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR PANTHER; PTHR14186; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14186:SF21; KAZAL-TYPE SERINE PROTEASE INHIBITOR DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR PIRSF; PIRSF018239; IGFBP_rP_mac25; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000604080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..292
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033048501"
FT DOMAIN 41..120
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 163..260
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWI79351.1"
FT NON_TER 292
FT /evidence="ECO:0000313|EMBL:NWI79351.1"
SQ SEQUENCE 292 AA; 32396 MW; 3493BB6090565B3F CRC64;
LSISCLVFSL LSLHWALLQL GQAFPSTSDY LQRGWQRLLE EGEGCTECQP EECPMPRGCL
AGTVRDACDC CWECANLEGQ ICDLDNTNHF YGKCGEHLEC RLDAGDLSHG EVPEPQCACL
SHLALCGSDG KTYAQICRFL EAAHAHPDAN LTVAHEGPCE SEPQITSPPY DTWNITGQDV
IFGCEVFAYP MASIEWRKDG TEMLLPGDDP HISVQFRGGP QKYEVTGWLQ IQGVRVTDEG
TYRCFARNRV GEVVALASLT VFTPDQLNLT DFSLPKPRVT PEDYGESEED YY
//
