ID A0A851EJ00_9CORV Unreviewed; 415 AA.
AC A0A851EJ00;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 08-OCT-2025, entry version 17.
DE RecName: Full=Probable JmjC domain-containing histone demethylation protein 2C {ECO:0000256|ARBA:ARBA00069433};
DE AltName: Full=Jumonji domain-containing protein 1C {ECO:0000256|ARBA:ARBA00079980};
DE Flags: Fragment;
GN Name=Jmjd1c_1 {ECO:0000313|EMBL:NWI83239.1};
GN ORFNames=DRYGAM_R00890 {ECO:0000313|EMBL:NWI83239.1};
OS Dryoscopus gambensis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Corvoidea; Malaconotidae; Dryoscopus.
OX NCBI_TaxID=85069 {ECO:0000313|EMBL:NWI83239.1, ECO:0000313|Proteomes:UP000604080};
RN [1] {ECO:0000313|EMBL:NWI83239.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B10K-DU-002-56 {ECO:0000313|EMBL:NWI83239.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NWI83239.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable histone demethylase that specifically demethylates
CC 'Lys-9' of histone H3, thereby playing a central role in histone code.
CC Demethylation of Lys residue generates formaldehyde and succinate. May
CC be involved in hormone-dependent transcriptional activation, by
CC participating in recruitment to androgen-receptor target genes.
CC {ECO:0000256|ARBA:ARBA00056982}.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the JHDM2 histone demethylase family.
CC {ECO:0000256|ARBA:ARBA00037987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NWI83239.1}.
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DR EMBL; WEIT01038374; NWI83239.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A851EJ00; -.
DR Proteomes; UP000604080; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:TreeGrafter.
DR GO; GO:0000118; C:histone deacetylase complex; IEA:TreeGrafter.
DR GO; GO:0031490; F:chromatin DNA binding; IEA:TreeGrafter.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0032454; F:histone H3K9 demethylase activity; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR FunFam; 2.60.120.650:FF:000008; Probable JmjC domain-containing histone demethylation protein 2C; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR045109; LSDs-like.
DR PANTHER; PTHR12549; JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN; 1.
DR PANTHER; PTHR12549:SF6; JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 2C-RELATED; 1.
DR Pfam; PF02373; JmjC; 1.
DR SMART; SM00558; JmjC; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000604080};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 221..415
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NWI83239.1"
FT NON_TER 415
FT /evidence="ECO:0000313|EMBL:NWI83239.1"
SQ SEQUENCE 415 AA; 46518 MW; 689D18864A1FECA1 CRC64;
PPASQNNEQG STLRDLLTTT AGKLRLGSTD AGIAFAPVYS TGAASGKSGR TMPNILDDII
ASVVENKIPP NRAPKINVKS EIKDEPKDDK KCIQDDCSKR YSDIQYSWIC DKHVLWLRDH
KNSNNWKLFK ECWKQGRPVL VSGMHKKMNF SLWKAESISL DFGNQQADIL NCKDSIISNT
NVKEFWDGFE DVSKRQKVKN GETALLKLKD WPSGEDFKAM MPARYEDLLK SLPLPEYCSP
EGKLNLASHL PGFFVRPDLG PRLCSAYGVA ATKDHDIGTT NLHIEVSDVV NILVYVGIAK
GNGVLSKSGV LKKLEEEDLD DLLRKRLKDS SELPGALWHI YAGKDADKIR EFLQKIAKEQ
GLEVLPEHDP IRDQSWYVNK KLRQRLFEEY GVKTCTVIQF LGDAIILPAG ALHQV
//
