ID A0A851PNJ3_ANHAN Unreviewed; 622 AA.
AC A0A851PNJ3;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 28-JAN-2026, entry version 15.
DE SubName: Full=MTMR6 protein {ECO:0000313|EMBL:NXC67284.1};
DE Flags: Fragment;
GN Name=Mtmr6 {ECO:0000313|EMBL:NXC67284.1};
GN ORFNames=ANHANH_R07239 {ECO:0000313|EMBL:NXC67284.1};
OS Anhinga anhinga (Anhinga) (Plotus anhinga).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Aequornithes; Suliformes;
OC Anhingidae; Anhinga.
OX NCBI_TaxID=56067 {ECO:0000313|EMBL:NXC67284.1, ECO:0000313|Proteomes:UP000657035};
RN [1] {ECO:0000313|EMBL:NXC67284.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B10K-CU-031-38 {ECO:0000313|EMBL:NXC67284.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXC67284.1}.
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DR EMBL; WBMU01000370; NXC67284.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A851PNJ3; -.
DR OrthoDB; 271628at2759; -.
DR Proteomes; UP000657035; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005635; C:nuclear envelope; IEA:TreeGrafter.
DR GO; GO:0106018; F:phosphatidylinositol-3,5-bisphosphate phosphatase activity; IEA:TreeGrafter.
DR GO; GO:0004438; F:phosphatidylinositol-3-phosphate phosphatase activity; IEA:TreeGrafter.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:TreeGrafter.
DR CDD; cd14585; PTP-MTMR6; 1.
DR FunFam; 2.30.29.30:FF:000135; Myotubularin related protein 6; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR030564; Myotubularin.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR048994; PH-GRAM_MTMR6-9.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF34; MYOTUBULARIN-RELATED PROTEIN 6; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF21098; PH-GRAM_MTMR6-like; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000657035}.
FT DOMAIN 124..500
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT COILED 510..544
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 336
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-1"
FT BINDING 273..274
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 336..342
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXC67284.1"
FT NON_TER 622
FT /evidence="ECO:0000313|EMBL:NXC67284.1"
SQ SEQUENCE 622 AA; 71614 MW; 73C719ABB499E02E CRC64;
CSPSFFLQVE QVKLLDRFST SNKSLTGTLY LTATHLLFID ASQRETWILH HHIASVEKLP
LTTSGCPLVI QCKNFRIVHF VVPRERDCHD IYNSLLQLSR TAKYEELYAF SYNPKQNESE
QVKGWQLIDL AEEYKRMGVP NSNWQLSDAN RDYKICETYP RELYVPRTAS KPIIVGSSKF
RSKGRFPVLS YYHKNKEAAI CRCSQPLSGF SARCLEDEHM LQAISKANPS NRYMYVMDTR
PKLNAMANRA AGKGYENEDN YSNIRFQFVG IENIHVMRSS LQKLLEVSGT KGLSVNDFLS
GLENSGWLRH IKAVLDAAVF LVKAIAVESA SVLVHCSDGW DRTSQVCSLG ALLLDSYYRT
IKGFMVLIEK DWISFGHKFS DRCCQLDSDP KEISPVFTQF LEGVWNLTEQ FPQAFEFNEA
FLLQIHEHVH SCQFGNFLGN CQKEREELKL KEKTYSLWPF LLNEQKKYRN PLYNPDSCPE
LTLLEPDTVS FNFKFWRNMY HQFDRSMHPR QSVFNLIMNM SEQNKQLEED IKELEAKIKR
RNGQSDAVLV KEYQQSAHPA PVALKTPPSF KKEQPLIPVN DTVRTIEGSN TADNRYSEFV
AEFSKAEPAV VSLEYGVARM TC
//
