ID A0A851QTB2_TYCCO Unreviewed; 900 AA.
AC A0A851QTB2;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 28-JAN-2026, entry version 16.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE Flags: Fragment;
GN Name=Znf598 {ECO:0000313|EMBL:NXC83465.1};
GN ORFNames=CERCOR_R13219 {ECO:0000313|EMBL:NXC83465.1};
OS Tychaedon coryphoeus (Karoo scrub-robin) (Erythropygia coryphaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Muscicapidae; Cercotrichas.
OX NCBI_TaxID=614051 {ECO:0000313|EMBL:NXC83465.1, ECO:0000313|Proteomes:UP000631545};
RN [1] {ECO:0000313|EMBL:NXC83465.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OUT-0024 {ECO:0000313|EMBL:NXC83465.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXC83465.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ZNF598/HEL2 family.
CC {ECO:0000256|ARBA:ARBA00035113}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXC83465.1}.
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DR EMBL; WBND01000201; NXC83465.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A851QTB2; -.
DR Proteomes; UP000631545; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0043022; F:ribosome binding; IEA:TreeGrafter.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:TreeGrafter.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:InterPro.
DR CDD; cd16615; RING-HC_ZNF598; 1.
DR InterPro; IPR057634; PAH_ZNF598/HEL2.
DR InterPro; IPR041888; RING-HC_ZNF598/HEL2.
DR InterPro; IPR044288; ZNF598/HEL2.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR059042; Znf_C2H2_ZNF598.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR22938:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZNF598; 1.
DR PANTHER; PTHR22938; ZINC FINGER PROTEIN 598; 1.
DR Pfam; PF23202; PAH_ZNF598; 1.
DR Pfam; PF25447; RING_ZNF598; 1.
DR Pfam; PF23208; zf_C2H2_ZNF598; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Ligase {ECO:0000313|EMBL:NXC83465.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000631545};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 20..60
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 309..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..353
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..380
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXC83465.1"
FT NON_TER 900
FT /evidence="ECO:0000313|EMBL:NXC83465.1"
SQ SEQUENCE 900 AA; 100562 MW; 279F4DE5428E974C CRC64;
AEAAMAAMAG AGPGPAEGPC VLCCGELDVV ALGRCEHPIC YRCSVRMRAL CGVRYCAVCR
EELRQVVFGR KLPSFSSIAL HQLQHEKKYD IYFMDAEVYG LYRKLLQHEC SLCPDAKPFN
TFADLEQHMR KQHELFCCKL CVKHLKIFTY ERKWYSRKDL ARHRIHGDPD DTSHRGHPLC
KFCDERYLDN DELLKHLRRD HYFCHFCDSE GAQEYYRQAH HWDGDYEYLR EHFREKHFLC
EEGRCSSEQF THAFRTEIDY KAHKSACHSK SRAEARQNRH IDLQFTYTPR HPRRGDGVVG
AEDYEEVDRF NRQGRAGRLS SRGNQQNRRG SWRYKREEED RDVAAAVRAS VAAKRQEEKK
RVEDKEEGSR GRKEDLRDPD VLGSKRLPKS SNDVTGECWA RPAAAGHLWK VPSEAAANGA
LSQDDFPAIG SAAGPLQGPA QPTLVKLKEE DFPSLSSSAA PTISSGMSLT YTATARKAAF
QEEDFPALVS KVKPTNKTVT HITSAWNNGS SKNVVKAMSN PCVNQPAKKP SLNTSKGSKK
SNKLCESDDE DGGGGLTTQE IRSTPTMFDV SSLLAASTSQ TFTKVGKKKK MGVEKQSPSS
PRPSQEAPLP RPATEKPPEA EQPCKVFPAA HGPDRATAVV NGHSEKPAAG CAAPKEPPGL
KKPPVTNKCP LPQEDFPALG SSGSARMPPP PGFNSVVLLK NPPPPPGLSV PVSKPPPGFA
VIPSSTISEP VTTALKEPKS CHGSYLIPEN FQQRNIQLIQ SIKEFLQSDE SKFNKFKTHS
GQFRQGLISA AQYYKSCREL LGENFKKIFK ELLVLLPDTA KQQELLSAHN DFRIREKQSS
NKPKKNKKNV WQTDSPAELD CYICPMCRQV LTQQDVVTHK ALHIEDEEFP SLQAISRIIS
//
