ID A0A852JF19_9PICI Unreviewed; 535 AA.
AC A0A852JF19;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 05-FEB-2025, entry version 13.
DE SubName: Full=SOCS5 protein {ECO:0000313|EMBL:NXX51107.1};
DE Flags: Fragment;
GN Name=Socs5 {ECO:0000313|EMBL:NXX51107.1};
GN ORFNames=TRILEU_R11521 {ECO:0000313|EMBL:NXX51107.1};
OS Tricholaema leucomelas (pied barbet).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Coraciimorphae;
OC Piciformes; Lybiidae; Tricholaema lacrymosa.
OX NCBI_TaxID=240729 {ECO:0000313|EMBL:NXX51107.1, ECO:0000313|Proteomes:UP000627253};
RN [1] {ECO:0000313|EMBL:NXX51107.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B10K-DU-002-37 {ECO:0000313|EMBL:NXX51107.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXX51107.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXX51107.1}.
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DR EMBL; WAAF01020199; NXX51107.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A852JF19; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000627253; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000627253};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 380..475
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 470..519
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 115..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXX51107.1"
FT NON_TER 535
FT /evidence="ECO:0000313|EMBL:NXX51107.1"
SQ SEQUENCE 535 AA; 61480 MW; 97E7BD5CC71D19A6 CRC64;
MDKVGKMWNN FKYRCQNLFS HEGGSQNENV VVNSNSCSSD KEKTVQITDL AQQPSSPLRE
NIAFQLGLSP SKNSARRNQN CVTEIPQIVE ISIEKENDSC VTTGARLARR DSYSRHAPWG
GKKKHSCSTK TQSSLDTEKR FGRTRSGLQR RERRYGVSSV HDMDMVSNRT VGSRSLRQRL
QDTVGLCFPM RPYSKQSKPL FSNKRKIHLS ELMLEKCPFP AGSDLAQKWH LIKQHTAPVS
PHSTFFDTFD PSLVSTEDEE DRLRERRRLS IEEGVDPPPN AQIHTFEATA QVNPLYKLGP
KLAPGMTELT GDKNLTPLSN CDSEEDTTTL CLQSRRQKQR QMSGESHSHL SRQGAWKVHT
QIDYIHCLVP DLLQITGNPC YWGVMDRYEA EALLEGKPEG TFLLRDSAQE DYLFSVSFRR
YNRSLHARIE QWNHNFSFDA HDPCVFHSST VTGLLEHYKD PSSCMFFEPL LTVSLNRTFP
FSLQYICRAV ICRCTTYDGI DDLPLPSMLQ DFLKEYHYKQ KVRVRWLERE PIKTK
//
