ID   A0A875RYM2_EENNA        Unreviewed;      1022 AA.
AC   A0A875RYM2;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   28-JAN-2026, entry version 12.
DE   RecName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN   Name=LAC4_2 {ECO:0000313|EMBL:QPG74631.1};
GN   ORFNames=FOA43_001963 {ECO:0000313|EMBL:QPG74631.1};
OS   Eeniella nana (Yeast) (Brettanomyces nanus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes;
OC   Pichiales; Pichiaceae; Brettanomyces.
OX   NCBI_TaxID=13502 {ECO:0000313|EMBL:QPG74631.1, ECO:0000313|Proteomes:UP000662931};
RN   [1] {ECO:0000313|EMBL:QPG74631.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CBS 1945 {ECO:0000313|EMBL:QPG74631.1};
RA   Roach M.J.R.;
RL   Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC       {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
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DR   EMBL; CP064813; QPG74631.1; -; Genomic_DNA.
DR   RefSeq; XP_038778196.1; XM_038922268.1.
DR   AlphaFoldDB; A0A875RYM2; -.
DR   SMR; A0A875RYM2; -.
DR   GeneID; 62195364; -.
DR   KEGG; bnn:FOA43_001963; -.
DR   OrthoDB; 408320at2759; -.
DR   Proteomes; UP000662931; Chromosome 2.
DR   GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0005990; P:lactose catabolic process; IEA:TreeGrafter.
DR   Gene3D; 2.70.98.10; -; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR004199; B-gal_small/dom_5.
DR   InterPro; IPR050347; Bact_Beta-galactosidase.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR017853; GH.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   InterPro; IPR006101; Glyco_hydro_2.
DR   InterPro; IPR006103; Glyco_hydro_2_cat.
DR   InterPro; IPR023230; Glyco_hydro_2_CS.
DR   InterPro; IPR006104; Glyco_hydro_2_N.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR006102; Ig-like_GH2.
DR   InterPro; IPR032312; LacZ_4.
DR   PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR   PANTHER; PTHR46323:SF1; LACTASE; 1.
DR   Pfam; PF02929; Bgal_small_N; 1.
DR   Pfam; PF00703; Glyco_hydro_2; 1.
DR   Pfam; PF02836; Glyco_hydro_2_C; 1.
DR   Pfam; PF02837; Glyco_hydro_2_N; 1.
DR   Pfam; PF16353; LacZ_4; 1.
DR   PRINTS; PR00132; GLHYDRLASE2.
DR   SMART; SM01038; Bgal_small_N; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154};
KW   Reference proteome {ECO:0000313|Proteomes:UP000662931}.
FT   DOMAIN          747..1020
FT                   /note="Beta galactosidase small chain/"
FT                   /evidence="ECO:0000259|SMART:SM01038"
SQ   SEQUENCE   1022 AA;  118228 MW;  A55A255DA347845F CRC64;
     MTTELIPHFL EDPTFVFENR LPTRAYTYDP EIFQSLNGEW SFKLFESPVL SPNLRTLRPS
     DFDAWSSIKV PSHWQLQNNG KYGYPYYTNV QFPFQIDIPN PPTLNPTGVY SRQFYISNPK
     ESNYRIRFEG VDNSYEVYMN QKYVGFNKGS RNGAEFDVQR FLVQGQNLIS VKVFQWSDSS
     YMEDQDQWWL SGIFRDVSLL TLPRAAHIEN YKVDPRFFDS NYKDARLLLD LNIVGTDYEF
     IKFTLFDFED PHKSIDTEAL LNDFDKPTTP AIKSVEFGKE DAQSTLKIPI GSPKHWTAED
     PYLYKYALQL IGTNGAPVHT VNNHIGFRQV ELLDGNIKVN GRTILFRGVN RHEHHPRCGR
     AVPLEFVIRD LALMKSHNIN AVRTSHYPNH PRVYNFFDKL GFWVIDEADL ETHGVQEPYN
     RYKDIITENS DTKILHHDVS VRYVSSNPDY KIAYLDRASQ LVLRDINHPS VIIWSLGNES
     GYGTNHKLMY QLIKKLDSSR LVHYEGDVNA ETTDMYSFMY PSLNKMEKWR KHRTDSNGKF
     DKPLILCEYS HAMGNGPGSL KEYQDLFYTY KFYQGGFIWE WANHGIEFQT ISKSDGKLHK
     AYAYGGDFNE EINDGVFIMD GLLNSEHNPT PGVVELKKVL EPVVIDVSSS KVKITNRYDF
     STTDHLKFLD VDNDKFLEVP SLKPNETVTL EVTTKNVSAV LNRDYGVLKA GFEVAWGQSE
     PELQAIDTSP KTIENEVAIE ETTRLVRVTS KSVFLEFNKL LGKIEHLKIG NRTMSTKYDG
     SSITFWRPPT NNDNAKDAPN WKKFNMNLVK QNVREVIVKK GTGEYLAKVI VKSRVGPPVF
     YYGFDVIQEY IIFPNRLTLH TTLKLTGDYQ PKDIPRIGYE FWLGDNYDSY EWSGRGPGES
     YPDKKLSQRF GTFNSNEVED FVYDYPQENG NHTDTHYLKI KYKNADKLVI SEKNKTFNFK
     VSDEYGVDEA DHPCDVKHYD QYYVRLDHAI HGVGSEACGP PVLDKYRLNI QNFDFTFDFG
     FD
//