ID A0A8B7QCY7_HIPAR Unreviewed; 135 AA.
AC A0A8B7QCY7;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=Secretin {ECO:0000256|ARBA:ARBA00015460};
GN Name=SCT {ECO:0000313|RefSeq:XP_019486629.1};
OS Hipposideros armiger (Great Himalayan leaf-nosed bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Rhinolophoidea;
OC Hipposideridae; Hipposideros.
OX NCBI_TaxID=186990 {ECO:0000313|Proteomes:UP000694851, ECO:0000313|RefSeq:XP_019486629.1};
RN [1] {ECO:0000313|RefSeq:XP_019486629.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_019486629.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR RefSeq; XP_019486629.1; XM_019631084.1.
DR AlphaFoldDB; A0A8B7QCY7; -.
DR GeneID; 109375634; -.
DR KEGG; hai:109375634; -.
DR CTD; 6343; -.
DR OrthoDB; 9417777at2759; -.
DR Proteomes; UP000694851; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:TreeGrafter.
DR GO; GO:1903640; P:negative regulation of gastrin-induced gastric acid secretion; IEA:TreeGrafter.
DR GO; GO:0090187; P:positive regulation of pancreatic juice secretion; IEA:TreeGrafter.
DR GO; GO:0090274; P:positive regulation of somatostatin secretion; IEA:TreeGrafter.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR015675; Prosecretin.
DR PANTHER; PTHR17378; SECRETIN; 1.
DR PANTHER; PTHR17378:SF1; SECRETIN; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR SMART; SM00070; GLUCA; 1.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Amidation {ECO:0000256|ARBA:ARBA00022815};
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000694851};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..135
FT /note="Secretin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5034943279"
FT DOMAIN 31..53
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT REGION 55..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 135 AA; 14715 MW; 1FBA3120B7366A6F CRC64;
MAPRALLLLL LLPPLLQGSA ARPAPPRAPR HSDGTFTSEL SRLRESARLQ RLLQGLVGKR
SEQDAENSTS WTHSATESAE GPLCLLWSHK AVLQAWMMPP TPPLDQAWSP WLPPGLKSGV
VVSEPAISAE TQRRS
//
