ID   A0A8B7RI57_HIPAR        Unreviewed;       440 AA.
AC   A0A8B7RI57;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   28-JAN-2026, entry version 19.
DE   SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|RefSeq:XP_019500756.1, ECO:0000313|RefSeq:XP_019500763.1};
GN   Name=SOCS4 {ECO:0000313|RefSeq:XP_019500756.1,
GN   ECO:0000313|RefSeq:XP_019500763.1};
OS   Hipposideros armiger (Great Himalayan leaf-nosed bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Rhinolophoidea;
OC   Hipposideridae; Hipposideros.
OX   NCBI_TaxID=186990 {ECO:0000313|Proteomes:UP000694851, ECO:0000313|RefSeq:XP_019500756.1};
RN   [1] {ECO:0000313|RefSeq:XP_019500756.1, ECO:0000313|RefSeq:XP_019500763.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_019500756.1,
RC   ECO:0000313|RefSeq:XP_019500763.1};
RG   RefSeq;
RL   Submitted (APR-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   RefSeq; XP_019500756.1; XM_019645211.1.
DR   RefSeq; XP_019500763.1; XM_019645218.1.
DR   AlphaFoldDB; A0A8B7RI57; -.
DR   GeneID; 109384171; -.
DR   KEGG; hai:109384171; -.
DR   CTD; 122809; -.
DR   OrthoDB; 8820570at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000694851; Unplaced.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd10385; SH2_SOCS4; 1.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR035864; SOCS4_SH2.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694851};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          287..382
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          377..426
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..11
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  50511 MW;  6F9412FB757A5E31 CRC64;
     MAENNENNNK NLDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSENCSDAE TVNAVEKTEV
     PLRSQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR
     KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPINPKSDE LVSTDLSQSE LRDGQLRQRR
     NIEEEMNCFS HPTVQPCVIT TNNASCRGGP MSGSVMNLVS NNSIEDSDMD SDDEIITLCT
     SSRKRNKPKW EMDEEILQLE TPPKYHTQID YVHCLVPDLL QINNNPCYWG VMDKYAAEAL
     LEGKPEGTFL LRDSAQEDYL FSVSFRRYSR SLHARIEQWN HNFSFDAHDP CVFHSPDITG
     LLEHYKDPSA CMFFEPLLST PLIRTFPFSL QHICRTVICN CTTYDGIDAL PIPSTMKLYL
     KEYHYKSKVR VLRIDAPEQC
//