ID A0A8B7U9J7_CASCN Unreviewed; 702 AA.
AC A0A8B7U9J7;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 28-JAN-2026, sequence version 2.
DT 28-JAN-2026, entry version 21.
DE RecName: Full=Zinc finger protein 750 {ECO:0000256|ARBA:ARBA00040216};
GN Name=Znf750 {ECO:0000313|RefSeq:XP_020016388.2};
OS Castor canadensis (American beaver).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Castoridae;
OC Castor.
OX NCBI_TaxID=51338 {ECO:0000313|RefSeq:XP_020016388.2};
RN [1] {ECO:0000313|RefSeq:XP_020016388.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_020016388.2; XM_020160799.2.
DR AlphaFoldDB; A0A8B7U9J7; -.
DR KEGG; ccan:109684409; -.
DR CTD; 79755; -.
DR OrthoDB; 8933073at2759; -.
DR Proteomes; UP001732720; Chromosome 11.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; IEA:TreeGrafter.
DR InterPro; IPR039363; ZNF750.
DR InterPro; IPR039064; ZNF750_Znf.
DR PANTHER; PTHR14678; PROLINE-RICH PROTEIN 35-RELATED; 1.
DR PANTHER; PTHR14678:SF1; ZINC FINGER PROTEIN 750; 1.
DR Pfam; PF15269; zf-C2H2_7; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP001732720};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 6..57
FT /note="Zinc finger protein 750-like zinc finger"
FT /evidence="ECO:0000259|Pfam:PF15269"
FT REGION 61..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 702 AA; 76141 MW; 08802F60DE779423 CRC64;
MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVSEQD
RVPKCPKSSS LDPKQTHQPE PATKLATSKS LTNGLSSFDP KTPQGFTSED TKENLELRAR
GTHKCPQKPA LQKEMAPDAV LSTQPGLDSG LRPSAFVPVG EHRLRGPEDT EAPEILALTS
PTTKATSFHA KSAFHTPGYP WKAGSPFLPP EFPHKIPTTK GFSAISPYVH PAIPEYPPPF
YTEHGLAAIY SPYLLTGNAP ECDTTLLSVY GAQDQRHFLP HPGPLPKHLN PSPSTYEHYR
FLQQYHSNLP IPYGFYRPES AFSSYGLRLP PVTGITRDQS SRLLEEATLA YPVSSPSELN
SPNSHKKHTE FEKESPTPKA KDPSKDGQRD TEGAKMSPRA GSAATGSPGR PSPTNFTQTS
QTCEGLYDLS NKAASMGTLG RLQQPEQSST AFKPVPHSQT TANRAESPKS LQAMDRDPPD
QTGSASPTME APPSSPEDGS RIGPLNLSKR SEATPAAAHG PMYSGSAQEE SLGFSELQDL
PLNLSVKDPC NARALRPALP SPPHGTGPAA AAPKTEEKRS GDRPTHIETQ RVEAPNGKGP
EAHVVDSSEE QKQTAAVALC QLAAYSPGNV RVGDGEPAVQ DCQDVPTLGS TENQETQCDP
RPKGQKRTSQ RDAGKSQQGA KKLKPSDTAP RVLTLRKRTR VS
//
