ID A0A8B7UUN5_CASCN Unreviewed; 582 AA.
AC A0A8B7UUN5;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2025, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 {ECO:0000256|ARBA:ARBA00068549};
DE AltName: Full=110 kDa cell membrane glycoprotein {ECO:0000256|ARBA:ARBA00083501};
DE AltName: Full=Adhesion-regulating molecule 1 {ECO:0000256|ARBA:ARBA00078376};
DE AltName: Full=Rpn13 homolog {ECO:0000256|ARBA:ARBA00079688};
GN Name=Adrm1 {ECO:0000313|RefSeq:XP_020023371.1};
OS Castor canadensis (American beaver).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Castoridae;
OC Castor.
OX NCBI_TaxID=51338 {ECO:0000313|RefSeq:XP_020023371.1};
RN [1] {ECO:0000313|RefSeq:XP_020023371.1}
RP IDENTIFICATION.
RC TISSUE=Leukocyte {ECO:0000313|RefSeq:XP_020023371.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC regulatory subunits (RP). Interacts with the proteasomal scaffolding
CC protein PSMD1. Interacts with deubiquitinase UCHL5; this interaction
CC activates the auto-inhibited UCHL5 by deoligomerizing it. Interacts
CC with UBQLN2 and ubiquitin. {ECO:0000256|ARBA:ARBA00061738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
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DR RefSeq; XP_020023371.1; XM_020167782.1.
DR RefSeq; XP_020023371.2; XM_020167782.2.
DR AlphaFoldDB; A0A8B7UUN5; -.
DR GeneID; 109689085; -.
DR KEGG; ccan:109689085; -.
DR CTD; 11047; -.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP001732720; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 1.10.2020.20:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Receptor {ECO:0000313|RefSeq:XP_020023371.1};
KW Reference proteome {ECO:0000313|Proteomes:UP001732720}.
SQ SEQUENCE 582 AA; 60994 MW; D4577EBAE37765ED CRC64;
MADRWLPADL ERWLHRGLRK RRRGHLPLGL HHSGARSHSL ASACPLGAAP WGTPASRLRT
AVAVGSWLAN PRGRRQRPPP LPYDTATIGA ALGCARLGPA LPPEGSRRRG GGTGRGERDG
RPHEPIESGI GPAVRLTEPN RRRERQRGGP SVGFRRGPAG AEEEELARTA RLGRVMTTSG
ALFPSLVPGS RGSSNKYLVE FRAGKMSLKG TTVTPDKRKG LVYIQQTDDS LIHFCWKDRT
SGTVEDDLII FPDDCEFKRV PQCPSGRVYV LKFKAGSKRL FFWMQEPKTD QDEEHCRKVN
EYLNNPPMPG ALGTSGSGGH ELSALGGEGG LQSLLGNMSH SQLMQLIGPA GLGGLGGLGA
LTGPGLASLL GSGGPPASSS SSSSRSQSAA VTPSSSTSSA RATPAPSAPA AASATSPSPA
PSSGNGTSTA ASPTQPIQLS DLQSILATMN VPAGPGGGQQ VDLASVLTPE IMAPILANAD
VQERLLPYLP SGESLPQTAD EIQNTLTSPQ FQQALGMFSA ALASGQLGPL MCQFGLPAEA
VEAANKGDVE AFAKAMQNNA KSEQKEGDTK DKKDEEEDMS LD
//
