ID A0A8B7ZK18_ACAPL Unreviewed; 1822 AA.
AC A0A8B7ZK18;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE SubName: Full=Collagen alpha-1(II) chain-like isoform X1 {ECO:0000313|RefSeq:XP_022105968.1};
GN Name=LOC110987500 {ECO:0000313|RefSeq:XP_022105968.1};
OS Acanthaster planci (Crown-of-thorns starfish).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea;
OC Valvatacea; Valvatida; Acanthasteridae; Acanthaster.
OX NCBI_TaxID=133434 {ECO:0000313|Proteomes:UP000694845, ECO:0000313|RefSeq:XP_022105968.1};
RN [1] {ECO:0000313|RefSeq:XP_022105968.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022105968.1; XM_022250276.1.
DR GeneID; 110987500; -.
DR KEGG; aplc:110987500; -.
DR OrthoDB; 5983381at2759; -.
DR Proteomes; UP000694845; Unplaced.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050938; Collagen_Structural_Proteins.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR37456:SF6; COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2; 1.
DR PANTHER; PTHR37456; SI:CH211-266K2.1; 1.
DR Pfam; PF01391; Collagen; 7.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Reference proteome {ECO:0000313|Proteomes:UP000694845};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1822
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5034069432"
FT DOMAIN 42..233
FT /note="Thrombospondin-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00210"
FT REGION 232..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..621
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..798
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..900
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..911
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..971
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1013
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1074
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1173
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1335..1347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1480
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1822 AA; 183667 MW; 407021D64F927433 CRC64;
MELRPALAAL RPHLLLVCLV GLLAAPSQTA ARKYVQSYDK LDFLILTGYP LPNGVKFAEG
LHGASAFHLE KGTNIGRMAF VIFPTDFTER FSDFTLLVTI KPESEDVGPL LVVTDNLQKT
VILALNVTQA GQDRHRVELV MRDVVTGTPA SASFLVPSLT DRWSQFSLSI INDMATLFFN
CSTYDSASLA RPEGWRLTIP QSGAVLVGNQ GSRLGTVASF EGTIQTLEMS NDPDAAEVRC
DSEPEPPKQR LYKRESSSSA LADALITNKD IPAQPSNSML NGSVHVAMQT SGFNSGGVKS
KYFSGGKEIE LGSAVGSGSP AGQGITEEPM ISSGMFESSM ESFLQTGTPP VSPDFLHGMD
TLSETPDMRT TSVSPPGISK AATDLPSKME TASKASIGME MVSQTPPGME MASKVSSGME
TSSKALSGIG PSSLPPDGMG MSSKVTPRME TVTKPFPVLG TTPETHSERT TTESPVTLPA
PTEKPDKFTE APSVTDAVTS SPPTVLTVTL PTVAPTGPIM SQLPSEMPVM TAKVSSPQMA
SDGQESVVVT TSTPLVKVIS ETPVSEDKVM SSPADHATPI PTEKATPKPT EKITPTPTGK
AAPSSTVNAT PAKTAEATTA PGDKFVSAPT GKAAPTTTDK AMPIPSRTLS SAPVEVVTPT
PIVKVISGSP GVPGVPGEPG PKGDPGIDGK DGAPGTNGKP GPPGTSGEKG EKGDKGSPGI
QGPKGALGDP GLTGPSGPEG LPGVAGPPGD KGVPGDTGPI GPSGSKGQKG EPGIGEPGPP
GQTVTPDPEK IRGAKGEQGK TGVPGPKGEK GDRGGIGLVG PQGDIGLQGA KGEKGDPGEG
LIGLQGPIGP IGPQGPQGDT GPVAELPEFF DLFEGSGLAD FRGQRGKKGQ DGQPGQAGPQ
GPVGPPGPPG PQGNQGAPGS PGMPGVPGTP GRPGTVGMNY TGLNGLCCRD GLNGSQGPPG
IQGPPGPPGP PGQNGTAGTS GETGKPGVPG IEGPPGMKGD PGIAGPPGPP GPPGKIYIMP
TDATPTAISK LFTDGDASAG SGSPPQITKS PVNGGVDLIP GEPGAPGPPG PQGPPGATGE
RGEIGLLGER GPKGDKGSPG TQGIQGPKGD TGPQGLPGKN GKDGREGPQG KQGERGVGLP
GDKGDAGSMG PSGMPGEQGI MGPPGPPGPP GPPGEVMIDV DGQMSEKGEK GDSGEVGPRG
PRGQKGEAGL NGIPGFHGTK GDRGERGPAG MDGAPGAQGD MGPKGDQGPE GIQGRDGLDG
MPGPRGPQGE KGEPYIPDES ALVLLKGMRG PRGPRGPKGH FGIPGRPGNH GDIGPPGLSG
PAGADGVPGI GIPGEKGEQG MKGEKGEPAI IGTALPLASG VKGEKGDPGE RGPSGKRGPA
GPQGVPGFPG VNGLNGPKGE PGEPGEEGRP GAMGHPGVDG VPGSTGPQGP KGDKGSPGIG
LKGEQGRPGN PGPPGFGVPG IDGPQGPQGL PGPPGPPGPR GPTGASDLPE GSYIPIEGLP
GPQGFPGIDG EDGAPGEPGR PGDPGLRGPE GRPGEPGPRG FPGPASSGQL TSFSSINDMI
QQAASLTPGT IAFVTDVQEL YLRRDNGMTQ ILLGATFNLD PVPPLLTTST TTPSPQTHST
TEKVFTIPST KPGLPGPDLE LGDQPMLYMY ALNHPMTGDT YSEDSIGGLS GADSHCFQQA
QQARLPGTYR AFLSSRVQDV KSVVNKDYHH LPVANAKDEI MFQSWAGIFN GKGATFDSDK
HIYSFDGKDV MTDDEWDQKY IWHGSYVDGR RMADSYCEEW RTYDGSASGQ ASPLGSHKLL
GQETQLCSNA LVVLCVQVSP DT
//
