ID A0A8B8E2F5_CRAVI Unreviewed; 470 AA.
AC A0A8B8E2F5;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE SubName: Full=Fork head domain-containing protein FD4-like {ECO:0000313|RefSeq:XP_022333968.1};
GN Name=LOC111130954 {ECO:0000313|RefSeq:XP_022333968.1};
OS Crassostrea virginica (Eastern oyster).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=6565 {ECO:0000313|Proteomes:UP000694844, ECO:0000313|RefSeq:XP_022333968.1};
RN [1] {ECO:0000313|RefSeq:XP_022333968.1}
RP IDENTIFICATION.
RC TISSUE=Whole sample {ECO:0000313|RefSeq:XP_022333968.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_022333968.1; XM_022478260.1.
DR AlphaFoldDB; A0A8B8E2F5; -.
DR GeneID; 111130954; -.
DR KEGG; cvn:111130954; -.
DR OrthoDB; 5954824at2759; -.
DR Proteomes; UP000694844; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:TreeGrafter.
DR GO; GO:0030154; P:cell differentiation; IEA:TreeGrafter.
DR CDD; cd20035; FH_FOXQ2-like; 1.
DR FunFam; 1.10.10.10:FF:000352; Forkhead box Q2; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047519; FH_FOXQ2-like.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR050211; FOX_domain-containing.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF343; FORK-HEAD DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000694844}.
FT DOMAIN 90..182
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 90..182
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 188..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 470 AA; 53293 MW; 29A40D9F06791106 CRC64;
MCSSNPSAVM LPYGIKVPIS SPYIPSSQMA LELHRAQQFY DYSARMQYGI RGYPNALGLT
SYQSHPSVDH YLQHYLYKDP RIRYLHEEPK PNHSYIGLIA MAILSSRDKK LVLSDIYQWI
LDNYPYFRTR GPGWRNSIRH NLSLNDCFIK SGRSANGKGH YWAIHPANID DFQKGDFRRR
RAQRRVRRHM GLAVPDDDES PVPSPSDANW VDNDDTDLQV PKTSYSEQLS PGDVDDGQDI
STVAETSMAL TEEGKSIPER KSDHSILDVK VNESERLSPK KRRNFDMDSL LAPDDCVKHQ
KMDDGHTSSY EHTDNLEEGD IDVVTERTDS PSLQSTSESS REKENVLDLS PQKEEANQRN
ILSKNKDKNS PLFENSGIVF NSSVRGFTPI SPHSSTSGPG YSESWNSLNS YLPAFPVMGL
KNGLQHSLFL SRTISQIQQN RPGSHIPYRL HPERSSRLLP EGTQGRQITN
//
