ID A0A8B8YZK3_BALMU Unreviewed; 380 AA.
AC A0A8B8YZK3;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE RecName: Full=Peptide chain release factor 1-like, mitochondrial {ECO:0000256|ARBA:ARBA00070847};
DE AltName: Full=Mitochondrial translational release factor 1-like {ECO:0000256|ARBA:ARBA00082737};
GN Name=MTRF1L {ECO:0000313|Ensembl:ENSBMSP00010012126.1,
GN ECO:0000313|RefSeq:XP_036727264.1};
OS Balaenoptera musculus (Blue whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=9771 {ECO:0000313|Proteomes:UP000694857, ECO:0000313|RefSeq:XP_036727264.1};
RN [1] {ECO:0000313|Ensembl:ENSBMSP00010012126.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|Proteomes:UP000694857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG RefSeq;
RL Submitted (JUN-2024) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_036727264.1}
RP IDENTIFICATION.
RC TISSUE=Epidermis and Blubber {ECO:0000313|RefSeq:XP_036727264.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- FUNCTION: Mitochondrial peptide chain release factor that directs the
CC termination of translation in response to the peptide chain termination
CC codons UAA and UAG. {ECO:0000256|ARBA:ARBA00055528}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000256|ARBA:ARBA00010835}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_036727264.1; XM_036871369.1.
DR AlphaFoldDB; A0A8B8YZK3; -.
DR Ensembl; ENSBMST00010013491.1; ENSBMSP00010012126.1; ENSBMSG00010008898.1.
DR GeneID; 118905091; -.
DR KEGG; bmus:118905091; -.
DR CTD; 54516; -.
DR GeneTree; ENSGT00940000155683; -.
DR OMA; DHRVGFK; -.
DR OrthoDB; 2019491at2759; -.
DR Proteomes; UP000694857; Chromosome 12.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:Ensembl.
DR GO; GO:0070126; P:mitochondrial translational termination; IEA:Ensembl.
DR FunFam; 3.30.160.20:FF:000004; Peptide chain release factor 1; 1.
DR FunFam; 3.30.70.1660:FF:000004; Peptide chain release factor 1; 1.
DR FunFam; 3.30.70.1660:FF:000011; Peptide chain release factor 1-like, mitochondrial; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.30.70.1660; -; 1.
DR Gene3D; 6.10.140.1950; -; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR050057; Prokaryotic/Mito_RF.
DR NCBIfam; NF001859; PRK00591.1; 1.
DR PANTHER; PTHR43804; LD18447P; 1.
DR PANTHER; PTHR43804:SF3; PEPTIDE CHAIN RELEASE FACTOR 1-LIKE, MITOCHONDRIAL; 1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; Release factor; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000694857};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 245..261
FT /note="Prokaryotic-type class I peptide chain release
FT factors"
FT /evidence="ECO:0000259|PROSITE:PS00745"
FT COILED 71..113
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 380 AA; 43393 MW; 7DF6B351B4BF1B16 CRC64;
MRSRFLRSAF RGFWARQAAG PARRHVSCGS LPLEELFARG GPLRTFLERQ VRSEVQLPVR
RPELVAVAKL LNEKEQELQE TGHLLHDENE DLRKLAESEI TSCQKEIAQL KHQIILLLVP
SEEADEDDLL LEVTAGVGGQ EATLFTAEMF DMYQKYAAFR RWHFETLEYF PSEIGGLRHA
SASIGGSEAY KHMKFEGGVH RVQRVPKTEK QGRIHTSTMT VAILPQPTEI NLVINPKDLR
IDTKRASGAG GQHVNTTDSA VRIVHLPTGV VSECQQERSQ LKNREMAMKK LRAKLYSLRV
EEETSKRYNA RKIQIGTKGR SEKIRTYNFP QNRVTDHRIN KSLHDLETFM QGEYLLDELV
QSLKDYANYE SLVEIISSKV
//
