ID A0A8B9IWI2_9PSIT Unreviewed; 479 AA.
AC A0A8B9IWI2;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE SubName: Full=HtrA serine peptidase 1 {ECO:0000313|Ensembl:ENSACOP00000010592.1};
OS Amazona collaria (yellow-billed parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=241587 {ECO:0000313|Ensembl:ENSACOP00000010592.1, ECO:0000313|Proteomes:UP000694522};
RN [1] {ECO:0000313|Ensembl:ENSACOP00000010592.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSACOP00000010592.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR AlphaFoldDB; A0A8B9IWI2; -.
DR Ensembl; ENSACOT00000010962.1; ENSACOP00000010592.1; ENSACOG00000007363.1.
DR Proteomes; UP000694522; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:TreeGrafter.
DR GO; GO:0012501; P:programmed cell death; IEA:TreeGrafter.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06785; cpPDZ_HtrA-like; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR FunFam; 2.40.10.120:FF:000002; HtrA serine peptidase 3; 1.
DR FunFam; 3.30.60.30:FF:000026; Insulin-like growth factor-binding protein 7; 1.
DR FunFam; 2.30.42.10:FF:000142; Serine protease HTRA1; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR22939; SERINE PROTEASE FAMILY S1C HTRA-RELATED; 1.
DR PANTHER; PTHR22939:SF13; SERINE PROTEASE HTRA1; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00121; IB; 1.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000694522};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..479
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5034390556"
FT DOMAIN 29..112
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 108..156
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 364..465
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
SQ SEQUENCE 479 AA; 50594 MW; CC4625B4311813FB CRC64;
MPLRGWSLLL LPLLLLLLAG PLPPAPAAPS AACPERCDRS RCPPLPPSCP GGAVLDGCGC
CRVCGAEEGE PCGGGGGPPC GEGLQCVVPP GAGVPASATV RKRAAAGRCL CSSTEPVCGS
DAVTYASQCQ LRAASRSAES LRQPPIIAIQ RGACGQGQEH PNSLRHKYNF IADVVEKIAP
AVVHIELFRK LPYSKREIPV ASGSGFIVSE DGLIVTNAHV VTNKNRVKVE LKNGETYEAK
IKDVDEKADI ALIKIDSQGK LPVLLLGQSA DLRPGEFVVA IGSPFSLQNT VTTGIVSTTQ
RGGKELGLRN SDMDYIQTDA IINYGNSGGP LVNLDGEVIG INTLKVTAGI SFAIPSDKIK
KFLTESHDRQ AKGKAITKKK YIGIRMMSLT PSKARELKDR HKDFPDVVSG AYVIEVIPET
PAEVGGLKDN DVIISINGQS ISSASDVSDI IKKDSTLNMV VRRGNEDVML TVVPEEIDP
//
