ID A0A8B9NKE2_9AVES Unreviewed; 619 AA.
AC A0A8B9NKE2;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE RecName: Full=Forkhead box protein P2 {ECO:0000256|ARBA:ARBA00040052};
OS Accipiter nisus (Eurasian sparrowhawk).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Accipitrimorphae;
OC Accipitriformes; Accipitridae; Accipitrinae; Accipiter.
OX NCBI_TaxID=211598 {ECO:0000313|Ensembl:ENSANIP00000023759.1, ECO:0000313|Proteomes:UP000694541};
RN [1] {ECO:0000313|Ensembl:ENSANIP00000023759.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSANIP00000023759.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A8B9NKE2; -.
DR Ensembl; ENSANIT00000024549.1; ENSANIP00000023759.1; ENSANIG00000015147.1.
DR Proteomes; UP000694541; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR CDD; cd20065; FH_FOXP2; 1.
DR FunFam; 1.20.5.340:FF:000005; Forkhead box P1, isoform CRA_f; 1.
DR FunFam; 1.10.10.10:FF:000010; Forkhead box P2 isoform B; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047412; FH_FOXP1_P2.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR050998; FOXP.
DR InterPro; IPR032354; FOXP-CC.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR PANTHER; PTHR45796:SF9; FORKHEAD BOX PROTEIN P2; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16159; FOXP-CC; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000694541};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 408..481
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 408..481
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 191..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 70..119
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 196..209
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..363
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..619
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 69293 MW; E598A304A088B068 CRC64;
GLKSPKGSDK QRPLQVPVSV AMMTPQVITP QQMQQILQQQ VLSPQQLQAL LQQQQAVMLQ
QQQLQEFYKK QQEQLHLQLL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQH
PGKQAKEVGA KPLADAQQEQ FRVFSRSKDA AIKDFGALFH FIAGLSPAEI QQLWKEVTGV
HSMEDNGIKH GGLDLTTNNS SSTTSSTTSK ASPPITHHSI VNGQSSVLNA RRDSSSHEET
GASHTLYGHG VCKWPGCESV CEDFGQFLKH LNNEHALDDR STAQCRVQMQ VVQQLEIQLS
KERERLQAMM THLHMRPSEP KPSPKPLNLV SSVTMSKNML ETSPQSLPQT PTTPTAPVTP
ITQGPSVITP ASVPNVGAIR RRHSDKYNIP MSSEIAPNYE FYKNADVRPP FTYATLIRQA
IMESSDRQLT LNEIYSWFTR TFAYFRRNAA TWKNAVRHNL SLHKCFVRVE NVKGAVWTVD
EVEYQKRRSQ KITGSPTLVK NIPTSLGYGA ALNASLQAAL AESSLPLLSN PGLINNASSG
LLQAVHEDLN GSLDHIDSNG NSSPGCSPQP HIHSIHVKEE PVIAEDEDCP MSLVTTANHS
PELEDDREIE EEPLSEDLE
//
