ID A0A8B9QKY9_APTOW Unreviewed; 335 AA.
AC A0A8B9QKY9;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE RecName: Full=Bardet-Biedl syndrome 5 protein homolog {ECO:0000256|PIRNR:PIRNR010072};
OS Apteryx owenii (Little spotted kiwi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Apterygiformes; Apterygidae; Apteryx.
OX NCBI_TaxID=8824 {ECO:0000313|Ensembl:ENSAOWP00000028405.1, ECO:0000313|Proteomes:UP000694424};
RN [1] {ECO:0000313|Ensembl:ENSAOWP00000028405.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSAOWP00000028405.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: Required for ciliogenesis. {ECO:0000256|PIRNR:PIRNR010072}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309, ECO:0000256|PIRNR:PIRNR010072}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC centriolar satellite {ECO:0000256|ARBA:ARBA00004607}.
CC -!- SIMILARITY: Belongs to the BBS5 family. {ECO:0000256|ARBA:ARBA00005822,
CC ECO:0000256|PIRNR:PIRNR010072}.
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DR AlphaFoldDB; A0A8B9QKY9; -.
DR Ensembl; ENSAOWT00000032180.1; ENSAOWP00000028405.1; ENSAOWG00000019125.1.
DR Proteomes; UP000694424; Unplaced.
DR GO; GO:0034464; C:BBSome; IEA:UniProtKB-UniRule.
DR GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR FunFam; 2.30.29.30:FF:000232; Bardet-Biedl syndrome 5 isoform 1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR006606; BBL5.
DR InterPro; IPR030804; BBS5/fem-3.
DR InterPro; IPR014003; BBS5_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR Pfam; PF07289; BBL5; 1.
DR PIRSF; PIRSF010072; DUF1448; 1.
DR SMART; SM00683; DM16; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR010072};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|PIRNR:PIRNR010072};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|PIRNR:PIRNR010072};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR010072};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR010072};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR010072};
KW Reference proteome {ECO:0000313|Proteomes:UP000694424}.
FT DOMAIN 22..76
FT /note="BBSome complex member BBS5 PH"
FT /evidence="ECO:0000259|SMART:SM00683"
FT DOMAIN 152..206
FT /note="BBSome complex member BBS5 PH"
FT /evidence="ECO:0000259|SMART:SM00683"
SQ SEQUENCE 335 AA; 38196 MW; 3209EF853711D886 CRC64;
VEVIDCLGQL SNIQQMKMRP GEVLIDCLDS VEDTKGNNGD RGRLLVTNLR IIWHSLSLPR
VNLSVGYNCI INITTRTANS KLRGQTEALY ILTKCNNTRF EFIFTNVIPG SPRLFTSVIA
VHRAYETSKM YRDLKLRSAL IQNKQLRLLP QEQIYDKING VWNLSSDQGN LGTFFITNVR
IVWHANMNDS FNISIPYLQI RSIKIRDSKF GLAMVIESSQ QSGGYVLGFK IDPVEKLQEA
VKEINSLHRV YSANPIFGVD YEMEEKPQPL EDLTVEQVQD DVEIESDEQT DAFVAYFADG
NKQHDREPVF SEELGLAIEK LKDGFTLQEL WEVIS
//
