ID A0A8B9WLD0_BOSGR Unreviewed; 1293 AA.
AC A0A8B9WLD0;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 10-JUN-2026, entry version 21.
DE RecName: Full=Zinc finger transcription factor Trps1 {ECO:0000256|ARBA:ARBA00073694};
GN Name=TRPS1 {ECO:0000313|Ensembl:ENSBGRP00000007160.1};
OS Bos grunniens (Wild yak) (Bos mutus grunniens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=30521 {ECO:0000313|Ensembl:ENSBGRP00000007160.1, ECO:0000313|Proteomes:UP000694520};
RN [1] {ECO:0000313|Ensembl:ENSBGRP00000007160.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang S., Liu J.;
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBGRP00000007160.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- FUNCTION: Transcriptional repressor. Binds specifically to GATA
CC sequences and represses expression of GATA-regulated genes at selected
CC sites and stages in vertebrate development. Regulates chondrocyte
CC proliferation and differentiation. Executes multiple functions in
CC proliferating chondrocytes, expanding the region of distal
CC chondrocytes, activating proliferation in columnar cells and supporting
CC the differentiation of columnar into hypertrophic chondrocytes.
CC {ECO:0000256|ARBA:ARBA00058641}.
CC -!- SUBUNIT: Interacts with RNF4; regulates TRPS1 repressor activity.
CC Interacts specifically with the activator form of GLI3 (GLI3A) but not
CC with the repressor form (GLI3R). {ECO:0000256|ARBA:ARBA00066009}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR Ensembl; ENSBGRT00000008217.1; ENSBGRP00000007160.1; ENSBGRG00000004435.1.
DR GeneTree; ENSGT00940000157893; -.
DR Proteomes; UP000694520; Chromosome 18.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-KW.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR CDD; cd00202; ZnF_GATA; 1.
DR FunFam; 3.30.160.60:FF:001213; Transcriptional repressor GATA binding 1; 1.
DR FunFam; 3.30.50.10:FF:000020; Zinc finger transcription factor Trps1; 1.
DR FunFam; 3.30.160.60:FF:000674; zinc finger transcription factor Trps1 isoform X2; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR InterPro; IPR028440; TRPS1.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR47034; ZINC FINGER TRANSCRIPTION FACTOR TRPS1; 1.
DR PANTHER; PTHR47034:SF1; ZINC FINGER TRANSCRIPTION FACTOR TRPS1; 1.
DR Pfam; PF00320; GATA; 1.
DR Pfam; PF27058; Znf_C2H2_Trps1_1st; 1.
DR Pfam; PF27065; Znf_C2H2_Trps1_2nd; 1.
DR Pfam; PF27047; Znf_C2H2_Trps1_3rd; 1.
DR Pfam; PF27082; Znf_C2H2_Trps1_4th; 1.
DR Pfam; PF27088; Znf_C2H2_Trps1_5th; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SMART; SM00401; ZnF_GATA; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000694520};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 704..732
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 902..960
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT REGION 1..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1181..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1007
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1071
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1084
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1293 AA; 142300 MW; 3197CCE0E9444ABE CRC64;
MPYEVNAGYD FTNMVRKKNP PLRNIASEGE GQTLEPVGTE SKGPGKNKEF SADQMSENTD
QSDATELNNK EEHSLHVQDP SSSSKKDLKS SVLSEKAGFN YENSSKGGNL PSYSHDEVTE
RNMLAFSSPA AGGVCEPLKS PQRAEADDPQ DMACTPSGDS LEMKEDQKMS PKATEETGQV
QSGQANCQGS SPVSVASKNP QVPSDGGVRL NKSKTDVLVN DNPDPAPLSP ELQDFKCNIC
GYGYYGNDPT DLIKHFRKYH LGLHNRTRQD AELDSKILAL HNMVQFSHSK DFQKVNRSVL
SGVLQDISSS RPVLLNGTYD VQVTSGGTFI GIGRKTPDCQ GNTKYFRCKF CNFTYMGNSS
TELEQHFLQT HPNKIKASLP SSEGAKPSEK NSNKSIPAVR SGDAGDLGKW QDKITVKAGD
DSPVGYSVPI KPLDSRQNGT EATSYYWCKF CSFSCESSSS LKLLEHYGKQ HGGVQSGGLN
PELNDKLSRG SVINQNDLTK SAEGEPMTKA DKGSSGVKKK DFSSKGAEDN MVTSYNCQFC
DFRYSKSHGP DVIVVGPLLR HYQQLHNIHK CTIKHCPFCP RGLCSPEKHL GEITYPFACR
KSNCSHCALL LLHLSPGAAG SSRVKHQCHQ CSFSTPDVDV LLFHYESAHE SQASDVKQEG
SHLQGPDGQP AVKESKEHSC TKCDFITQVE EEISRHYRRA HSCYKCRQCS FTAAETQSLL
EHFNTVHCQE QDSTTANGEE DGHAVSTIKE EPKIDLKVYS LLNPDSKMGE PVAESVVKRE
KLEDKDGLKE KAWAESSSDD LRSVTWRGAD ILRGSPSYTQ ASLGLLTPVS GPQEQTKTLR
DSPNVEAAHL ARPIYGLAVD TKGFLQGAPA GGEKAGALPQ QYPASGESKS KDESQSLLRR
RRGSGVFCAN CLTTKTSLWR KNANGGYVCN ACGLYQKLHS TPRPLNIIKQ NNGEQIIRRR
TRKRLNPEAL QAEQLNKQQR ASSEEQVNGS PLERRSEDHL TEGHQREIPL PSLSKYEAQG
SLTKSHSAQQ PVLVSQTLDI HKRMQPLHIQ IKSPQESTGD PGNSSSVSEG KGSSERGSPI
EKYMRPAKHP NYSPPGSPIE KYQYPLFGLP FVHNDFQSEA DWLRFWSKYK LSVPGNPHYL
SHVPGLPNPC QNYVPYPTFN LPPHFSAVGS DNDIPLDLAI KHSRPGPTAN GASKEKTKAP
SNVKNEGPLN VVKTEKVDRS TQDELSTKCV HCGIVFLDEV MYALHMSCHG DSGPFQCSIC
QHLCTDKYDF TTHIQRGLHR NNAQVEKNGK PKE
//
