ID   A0A8C0APK2_9AVES        Unreviewed;       715 AA.
AC   A0A8C0APK2;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   28-JAN-2026, entry version 19.
DE   RecName: Full=Zinc finger protein 750 {ECO:0000256|ARBA:ARBA00040216};
OS   Buteo japonicus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Accipitrimorphae;
OC   Accipitriformes; Accipitridae; Accipitrinae; Buteo.
OX   NCBI_TaxID=224669 {ECO:0000313|Ensembl:ENSBJAP00000004982.1, ECO:0000313|Proteomes:UP000694555};
RN   [1] {ECO:0000313|Ensembl:ENSBJAP00000004982.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSBJAP00000004982.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A8C0APK2; -.
DR   Ensembl; ENSBJAT00000005125.1; ENSBJAP00000004982.1; ENSBJAG00000003579.1.
DR   Proteomes; UP000694555; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; IEA:TreeGrafter.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008544; P:epidermis development; IEA:TreeGrafter.
DR   InterPro; IPR039363; ZNF750.
DR   InterPro; IPR039064; ZNF750_Znf.
DR   PANTHER; PTHR14678; PROLINE-RICH PROTEIN 35-RELATED; 1.
DR   PANTHER; PTHR14678:SF1; ZINC FINGER PROTEIN 750; 1.
DR   Pfam; PF15269; zf-C2H2_7; 1.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694555};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          6..57
FT                   /note="Zinc finger protein 750-like zinc finger"
FT                   /evidence="ECO:0000259|Pfam:PF15269"
FT   REGION          82..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          378..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          642..715
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..92
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..391
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..479
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..492
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..583
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        646..676
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  79148 MW;  55D879624AA12B60 CRC64;
     MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVSEQD
     RIIKCPKTSS LEPKQINQLE STVKPTSSKS VTNGLSNLDS KPQYPFAKED AKENVELQNQ
     ATNTAIQGQK PAIQKELTPA STTAESAISM QPLLDSIVRP SAFVPVGEHR DSKGPENSEV
     SEIISLSNKS SPFHTKSAFH APSHPWKAGS TFLPEFPHKV APTKGFGSIS PYMQPMIPEY
     SPHFYEHRLA IYTPYLLPGN SECESSALSV YGTHDQRHFL PHPGPLPKPI NPSAYEHYRL
     FQQYHSTPPI PYGFCRPTDP PFYRFSHVAG INRDQNSHLM EETTLLYPAS LSPSQQYPLS
     SHKKQADYEK EITLLHAKSH SKDDQNEREN AKMSPLAGSA ATGSPGRPSP TNFTQTSHAC
     EGLFDLSNKS SSTSLGKYDQ PEENFTAFRP VRKSTDQPTL LQSVQTQQDR GESPTSINVT
     DEDSHTQNEC HNNEGSLSNT EEDTGIVPLN LSKKADTNTG PIHEHAYKTT SKTESQNFLE
     LQDMPLNLSV KDSCNTVSLK TSFHSPSHDN GAATSPNTEN ETSGADACNP KNPINSACDK
     SSFAAPCNEA QDLRIIDSCD EQKQTAAVAL CQLAAYSPSK VRMDNEGQSP QDSNASCTEA
     TLNSSDTQDT QCNQKVKGQK RTNQKESAKS QQGTKRVRPN DCSRVFTLRK RTRVS
//